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The fruit of acanthopanax senticosus harms improves arterial stiffness and blood pressure: A randomized, placebo-controlled trial
- Title
- The fruit of acanthopanax senticosus harms improves arterial stiffness and blood pressure: A randomized, placebo-controlled trial
- Authors
- Oh E.; Kim Y.; Park S.-Y.; Lim Y.; Shin J.-Y.; Kim J.Y.; Kim J.-H.; Rhee M.-Y.; Kwon O.
- Ewha Authors
- 권오란; 김유진; 임예니
- SCOPUS Author ID
- 권오란; 김유진; 임예니
- Issue Date
- 2020
- Journal Title
- Nutrition Research and Practice
- ISSN
- 1976-1457
- Citation
- Nutrition Research and Practice vol. 14, no. 4, pp. 322 - 333
- Keywords
- Acanthopanax; Cardiovascular diseases; Endothelial nitric oxide synthase; Pulse wave velocity; Vascular stiffness
- Publisher
- Korean Nutrition Society
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- BACKGROUND/OBJECTIVES: Arterial stiffness and endothelial dysfunction are 2 of the independent predictors for cardiovascular disease, while Acanthopanax senticosus Harms (ASH) is a traditional medicinal plant that can improve cardiovascular health. This study aimed to investigate the efficacy of the fruit of ASH on vascular function in apparently healthy subjects. SUBJECTS/METHODS: A 12-week, randomized, double-blind, placebo-controlled design, consisting of healthy adults with at least 2 of the following 3 conditions: borderline high blood pressure (BP; 120 mmHg ≤ systolic BP ≤ 160 mmHg or 80 mmHg ≤ diastolic BP ≤ 100 mmHg), smoking (≥10 cigarettes/day), and borderline blood lipid levels (220 ≤ total cholesterol ≤ 240, 130 ≤ low density lipoprotein cholesterol ≤ 165, or 150 ≤ triglyceride ≤ 220 mg/dL). Randomly assigned 76 subjects who received a placebo or 2 doses of ASH fruit (low, 500 mg/day; high, 1,000 mg/day) completed the intervention. Brachial-ankle pulse wave velocity (baPWV), flow-mediated dilation, carotid intima-media thickness, and BP were measured both at baseline and following the 12-week intervention. Endothelial nitric oxide synthase (eNOS) phosphorylation was assessed by western blotting. RESULTS: Compared with the placebo group, the low-dose group showed more significant changes after the 12-week intervention period in terms of systolic BP (0.1 vs. −7.7 mmHg; P = 0.044), baPWV (31.3 vs. −98.7 cm/s; P = 0.007), and the ratio of phospho-eNOS/eNOS (0.8 vs. 1.22; P = 0.037). CONCLUSIONS: These results suggest that ASH fruit extract at 500 mg/day has the potential to improve BP and arterial stiffness via endothelial eNOS activation in healthy adults with smoking and the tendency of having elevated BP or blood lipid parameters. © 2020 The Korean Nutrition Society and the Korean Society of Community Nutrition.
- DOI
- 10.4162/nrp.2020.14.4.322
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
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