Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권오란 | * |
dc.contributor.author | 김유진 | * |
dc.contributor.author | 임예니 | * |
dc.date.accessioned | 2020-08-20T16:30:24Z | - |
dc.date.available | 2020-08-20T16:30:24Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1976-1457 | * |
dc.identifier.other | OAK-27359 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255077 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: Arterial stiffness and endothelial dysfunction are 2 of the independent predictors for cardiovascular disease, while Acanthopanax senticosus Harms (ASH) is a traditional medicinal plant that can improve cardiovascular health. This study aimed to investigate the efficacy of the fruit of ASH on vascular function in apparently healthy subjects. SUBJECTS/METHODS: A 12-week, randomized, double-blind, placebo-controlled design, consisting of healthy adults with at least 2 of the following 3 conditions: borderline high blood pressure (BP; 120 mmHg ≤ systolic BP ≤ 160 mmHg or 80 mmHg ≤ diastolic BP ≤ 100 mmHg), smoking (≥10 cigarettes/day), and borderline blood lipid levels (220 ≤ total cholesterol ≤ 240, 130 ≤ low density lipoprotein cholesterol ≤ 165, or 150 ≤ triglyceride ≤ 220 mg/dL). Randomly assigned 76 subjects who received a placebo or 2 doses of ASH fruit (low, 500 mg/day; high, 1,000 mg/day) completed the intervention. Brachial-ankle pulse wave velocity (baPWV), flow-mediated dilation, carotid intima-media thickness, and BP were measured both at baseline and following the 12-week intervention. Endothelial nitric oxide synthase (eNOS) phosphorylation was assessed by western blotting. RESULTS: Compared with the placebo group, the low-dose group showed more significant changes after the 12-week intervention period in terms of systolic BP (0.1 vs. −7.7 mmHg; P = 0.044), baPWV (31.3 vs. −98.7 cm/s; P = 0.007), and the ratio of phospho-eNOS/eNOS (0.8 vs. 1.22; P = 0.037). CONCLUSIONS: These results suggest that ASH fruit extract at 500 mg/day has the potential to improve BP and arterial stiffness via endothelial eNOS activation in healthy adults with smoking and the tendency of having elevated BP or blood lipid parameters. © 2020 The Korean Nutrition Society and the Korean Society of Community Nutrition. | * |
dc.language | English | * |
dc.publisher | Korean Nutrition Society | * |
dc.subject | Acanthopanax | * |
dc.subject | Cardiovascular diseases | * |
dc.subject | Endothelial nitric oxide synthase | * |
dc.subject | Pulse wave velocity | * |
dc.subject | Vascular stiffness | * |
dc.title | The fruit of acanthopanax senticosus harms improves arterial stiffness and blood pressure: A randomized, placebo-controlled trial | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 14 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 322 | * |
dc.relation.lastpage | 333 | * |
dc.relation.journaltitle | Nutrition Research and Practice | * |
dc.identifier.doi | 10.4162/nrp.2020.14.4.322 | * |
dc.identifier.wosid | WOS:000555885100003 | * |
dc.identifier.scopusid | 2-s2.0-85090685157 | * |
dc.author.google | Oh E. | * |
dc.author.google | Kim Y. | * |
dc.author.google | Park S.-Y. | * |
dc.author.google | Lim Y. | * |
dc.author.google | Shin J.-Y. | * |
dc.author.google | Kim J.Y. | * |
dc.author.google | Kim J.-H. | * |
dc.author.google | Rhee M.-Y. | * |
dc.author.google | Kwon O. | * |
dc.contributor.scopusid | 권오란(55713470100) | * |
dc.contributor.scopusid | 김유진(55766503300;57301428800;57207797446;57026608400) | * |
dc.contributor.scopusid | 임예니(37093382200) | * |
dc.date.modifydate | 20240123125010 | * |