View : 590 Download: 0
Platycodi radix beverage ameliorates postprandial lipemia response through lipid clearance of triglyceride-rich lipoprotein: A randomized controlled study in healthy subjects with a high-fat load
- Title
- Platycodi radix beverage ameliorates postprandial lipemia response through lipid clearance of triglyceride-rich lipoprotein: A randomized controlled study in healthy subjects with a high-fat load
- Authors
- Lee, Hansol; Lim, Yeni; Park, Soo-yeon; Cho, Soo-Muk; Choe, Jeong-Sook; Jeong, Sewon; Kwak, Jin Sook; Kwon, Oran
- Ewha Authors
- 권오란; 임예니
- SCOPUS Author ID
- 권오란; 임예니
- Issue Date
- 2018
- Journal Title
- NUTRITION RESEARCH AND PRACTICE
- ISSN
- 1976-1457
2005-6168
- Citation
- NUTRITION RESEARCH AND PRACTICE vol. 12, no. 5, pp. 371 - 377
- Keywords
- Platycodi radix; postprandial lipemia; pancreatic lipase; randomized controlled trial
- Publisher
- KOREAN NUTRITION SOC
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- BACKGROUND/OBJECTIVES: Elevation of postprandial lipemia characterized by a rise in triglyceride (TG)-rich lipoproteins can increase the risk of atherogenesis. The objective of this study was to investigate postprandial lipemia response to a single dietary fat/sugar load test and monitor beneficial changes induced by the consumption of Platycodi radix (AP) beverage in healthy subjects. SUBJECTS/METHODS: A total of 52 subjects were randomly assigned to either placebo or AP beverage group with a high-fat shake in a randomized controlled crossover trial. Postprandial blood was collected at 0, 1, 2, 4, and 6 h and analyzed for TG and lipoprotein lipase mass. Inhibition of pancreatic lipase was determined in vitro. RESULTS: AP inhibited pancreatic lipase activity in vitro (IC50 = 5 mg/mL). Compared to placebo beverage, AP beverage consumption with a high-fat shake induced significant increase of plasma lipoprotein lipase mass (P = 0.0111, beta estimate = 4.2948) with significant reduction in very low-density lipoprotein (VLDL) TG concentration (P = 0.038, beta estimate = -52.69) at 6 h. Based on significant correlation between high-fat dietary scores MEDFICTS and postprandial TG responses in VLDL (P = 0.0395, r = 0.2127), subgroup analysis revealed that 6 h-postprandial VLDL TG response was significantly decreased by AP consumption in subjects with MEDFICTS >= 40 (P = 0.0291, beta estimate = -7214). CONCLUSIONS: AP beverage might have potential to alleviate postprandial lipemia through inhibiting pancreatic lipase activity and elevating lipoprotein lipase mass. Subgroup analysis revealed that subjects with high-fat dietary pattern could be classified as responders to AP beverage among all subjects.
- DOI
- 10.4162/nrp.2018.12.5.371
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML