Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권오란 | * |
dc.contributor.author | 임예니 | * |
dc.date.accessioned | 2018-11-15T16:30:13Z | - |
dc.date.available | 2018-11-15T16:30:13Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1976-1457 | * |
dc.identifier.issn | 2005-6168 | * |
dc.identifier.other | OAK-23568 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/246496 | - |
dc.description.abstract | BACKGROUND/OBJECTIVES: Elevation of postprandial lipemia characterized by a rise in triglyceride (TG)-rich lipoproteins can increase the risk of atherogenesis. The objective of this study was to investigate postprandial lipemia response to a single dietary fat/sugar load test and monitor beneficial changes induced by the consumption of Platycodi radix (AP) beverage in healthy subjects. SUBJECTS/METHODS: A total of 52 subjects were randomly assigned to either placebo or AP beverage group with a high-fat shake in a randomized controlled crossover trial. Postprandial blood was collected at 0, 1, 2, 4, and 6 h and analyzed for TG and lipoprotein lipase mass. Inhibition of pancreatic lipase was determined in vitro. RESULTS: AP inhibited pancreatic lipase activity in vitro (IC50 = 5 mg/mL). Compared to placebo beverage, AP beverage consumption with a high-fat shake induced significant increase of plasma lipoprotein lipase mass (P = 0.0111, beta estimate = 4.2948) with significant reduction in very low-density lipoprotein (VLDL) TG concentration (P = 0.038, beta estimate = -52.69) at 6 h. Based on significant correlation between high-fat dietary scores MEDFICTS and postprandial TG responses in VLDL (P = 0.0395, r = 0.2127), subgroup analysis revealed that 6 h-postprandial VLDL TG response was significantly decreased by AP consumption in subjects with MEDFICTS >= 40 (P = 0.0291, beta estimate = -7214). CONCLUSIONS: AP beverage might have potential to alleviate postprandial lipemia through inhibiting pancreatic lipase activity and elevating lipoprotein lipase mass. Subgroup analysis revealed that subjects with high-fat dietary pattern could be classified as responders to AP beverage among all subjects. | * |
dc.language | English | * |
dc.publisher | KOREAN NUTRITION SOC | * |
dc.subject | Platycodi radix | * |
dc.subject | postprandial lipemia | * |
dc.subject | pancreatic lipase | * |
dc.subject | randomized controlled trial | * |
dc.title | Platycodi radix beverage ameliorates postprandial lipemia response through lipid clearance of triglyceride-rich lipoprotein: A randomized controlled study in healthy subjects with a high-fat load | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 371 | * |
dc.relation.lastpage | 377 | * |
dc.relation.journaltitle | NUTRITION RESEARCH AND PRACTICE | * |
dc.identifier.doi | 10.4162/nrp.2018.12.5.371 | * |
dc.identifier.wosid | WOS:000460194300002 | * |
dc.identifier.scopusid | 2-s2.0-85055187868 | * |
dc.author.google | Lee, Hansol | * |
dc.author.google | Lim, Yeni | * |
dc.author.google | Park, Soo-yeon | * |
dc.author.google | Cho, Soo-Muk | * |
dc.author.google | Choe, Jeong-Sook | * |
dc.author.google | Jeong, Sewon | * |
dc.author.google | Kwak, Jin Sook | * |
dc.author.google | Kwon, Oran | * |
dc.contributor.scopusid | 권오란(55713470100) | * |
dc.contributor.scopusid | 임예니(37093382200) | * |
dc.date.modifydate | 20240123125010 | * |