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Sesaminol glucosides improve cognitive deficits and oxidative stress in SAMP8 mice

Title
Sesaminol glucosides improve cognitive deficits and oxidative stress in SAMP8 mice
Authors
Um M.Y.Choi W.H.Ahn J.Y.Kim S.Kim M.K.Ha T.Y.
Ewha Authors
김미경
SCOPUS Author ID
김미경scopusscopus
Issue Date
2009
Journal Title
Food Science and Biotechnology
ISSN
1226-7708JCR Link
Citation
vol. 18, no. 6, pp. 1311 - 1315
Indexed
SCIE; SCOPUS; KCI WOS scopus
Abstract
The objective of this study was to investigate the effects of sesaminol glucosides (SG) on age-related cognitive deficits in senescence-accelerated mice P8 (SAMP8). Male SAMP8 (9 month-old) were randomly divided into 3 groups and received diets containing 0, 0.25, or 0.5% SG for 12 weeks. Step-through latency of the SAMP8 control group was higher than that of the senescence-accelerated resistant mice (SAMR) group, whereas it was lowered in the SG-supplemented group on the passive-avoidance test. In the Morris water maze, the escape latency of the SAMP8 control group was increased and recovered in the 0.5% SG-supplemented group. The SG supplementation significantly decreased thiobarbituric acid reactive substance (TBARS) levels in brains of the SAMP8. On the other hand, catalase, superoxide dismutase, and glutathione peroxidase activities in brains of the SG supplemented group decreased compared with the SAMP8 control group. These results suggest that SG could attenuate cognitive deficits caused by aging through its antioxidant capacity. © The Korean Society of Food Science and Technology.
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신산업융합대학 > 식품영양학과 > Journal papers
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