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Effect of vitamin E supplementation on antioxidant defense systems and humoral immune responses in young, middle-aged and elderly Korean women

Title
Effect of vitamin E supplementation on antioxidant defense systems and humoral immune responses in young, middle-aged and elderly Korean women
Authors
Park O.J.Kim H.Y.P.Kim W.K.Kim Y.J.Kim S.H.
Ewha Authors
김숙희
SCOPUS Author ID
김숙희scopusscopus
Issue Date
2003
Journal Title
Journal of Nutritional Science and Vitaminology
ISSN
0301-4800JCR Link
Citation
vol. 49, no. 2, pp. 94 - 99
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Free radical-mediated oxidative stress has been implicated in the pathogenesis of numerous chronic diseases. Vitamin E is known to play an important role in the free-radical quenching process. However, clinical trials with vitamin E have yielded contrasting results in the prevention of several diseases related to oxidative stress. This study was undertaken to investigate the antioxidative and humoral immunologic effects of vitamin E supplementation in three different age groups: young (mean age 32.7 ±5.7 y), middle-aged (mean age 47.0±5.0 y) and elderly (67.6±4.7 y) women. Volunteer subjects were given a supplement of 400 IU dl-α-tocopherol acetate for 6 wk. Thiobarbituric acid reacting substances (TBARS) in the plasma significantly decreased with vitamin E supplementation. In addition, the radical scavenger activities (RSA) of red blood cells significantly increased with vitamin E supplementation in all age groups. However, humoral immune response modulation was not observed following vitamin E supplementation. Even though there is no clear indication that vitamin E supplementation is necessary to improve the humoral immune functions, vitamin E supplementation may be beneficial to all adult age groups as a preventive measure for complications related to oxidative damage.
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신산업융합대학 > 식품영양학과 > Journal papers
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