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Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats

Title
Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats
Authors
Seo, SangjinLee, Mak-SoonChang, EugeneShin, YoonjinOh, SoojungKim, In-HwanKim, Yangha
Ewha Authors
김양하장유진
SCOPUS Author ID
김양하scopus; 장유진scopus
Issue Date
2015
Journal Title
NUTRIENTS
ISSN
2072-6643JCR Link
Citation
vol. 7, no. 9, pp. 8152 - 8169
Keywords
rutinobesityskeletal musclemitochondriaAMPK activity
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Decreased mitochondrial number and dysfunction in skeletal muscle are associated with obesity and the progression of obesity-associated metabolic disorders. The specific aim of the current study was to investigate the effects of rutin on mitochondrial biogenesis in skeletal muscle of high-fat diet-induced obese rats. Supplementation with rutin reduced body weight and adipose tissue mass, despite equivalent energy intake (p < 0.05). Rutin significantly increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as gene expression related to mitochondrial biogenesis, such as peroxisome proliferator-activated receptor coactivator-1 (PGC-1), nuclear respiratory factor-1 (NRF-1), transcription factor A (Tfam), and nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, sirtulin1 (SIRT1) in skeletal muscle (p < 0.05). Moreover, rutin consumption increased muscle adenosine monophosphate-activated protein kinase (AMPK) activity by 40% (p < 0.05). Taken together, these results suggested at least partial involvement of muscle mitochondria and AMPK activation in the rutin-mediated beneficial effect on obesity.
DOI
10.3390/nu7095385
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신산업융합대학 > 식품영양학과 > Journal papers
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