Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김양하 | * |
dc.contributor.author | 장유진 | * |
dc.date.accessioned | 2016-08-27T04:08:15Z | - |
dc.date.available | 2016-08-27T04:08:15Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 2072-6643 | * |
dc.identifier.other | OAK-15743 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/217671 | - |
dc.description.abstract | Decreased mitochondrial number and dysfunction in skeletal muscle are associated with obesity and the progression of obesity-associated metabolic disorders. The specific aim of the current study was to investigate the effects of rutin on mitochondrial biogenesis in skeletal muscle of high-fat diet-induced obese rats. Supplementation with rutin reduced body weight and adipose tissue mass, despite equivalent energy intake (p < 0.05). Rutin significantly increased mitochondrial size and mitochondrial DNA (mtDNA) content as well as gene expression related to mitochondrial biogenesis, such as peroxisome proliferator-activated receptor coactivator-1 (PGC-1), nuclear respiratory factor-1 (NRF-1), transcription factor A (Tfam), and nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, sirtulin1 (SIRT1) in skeletal muscle (p < 0.05). Moreover, rutin consumption increased muscle adenosine monophosphate-activated protein kinase (AMPK) activity by 40% (p < 0.05). Taken together, these results suggested at least partial involvement of muscle mitochondria and AMPK activation in the rutin-mediated beneficial effect on obesity. | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | rutin | * |
dc.subject | obesity | * |
dc.subject | skeletal muscle | * |
dc.subject | mitochondria | * |
dc.subject | AMPK activity | * |
dc.title | Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 7 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 8152 | * |
dc.relation.lastpage | 8169 | * |
dc.relation.journaltitle | NUTRIENTS | * |
dc.identifier.doi | 10.3390/nu7095385 | * |
dc.identifier.wosid | WOS:000361889400059 | * |
dc.identifier.scopusid | 2-s2.0-84942908152 | * |
dc.author.google | Seo, Sangjin | * |
dc.author.google | Lee, Mak-Soon | * |
dc.author.google | Chang, Eugene | * |
dc.author.google | Shin, Yoonjin | * |
dc.author.google | Oh, Soojung | * |
dc.author.google | Kim, In-Hwan | * |
dc.author.google | Kim, Yangha | * |
dc.contributor.scopusid | 김양하(8524160300) | * |
dc.contributor.scopusid | 장유진(30367468300) | * |
dc.date.modifydate | 20240123090847 | * |