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Mulberry Leaf Extract Improves Postprandial Glucose Response in Prediabetic Subjects: A Randomized, Double-Blind Placebo-Controlled Trial

Title
Mulberry Leaf Extract Improves Postprandial Glucose Response in Prediabetic Subjects: A Randomized, Double-Blind Placebo-Controlled Trial
Authors
Kim, Ji YeonOk, Hyang MokKim, JooheePark, Seok WonKwon, Sung WonKwon, Oran
Ewha Authors
권오란김주희
SCOPUS Author ID
권오란scopus; 김주희scopusscopus
Issue Date
2015
Journal Title
JOURNAL OF MEDICINAL FOOD
ISSN
1096-620XJCR Link1557-7600JCR Link
Citation
vol. 18, no. 3, pp. 306 - 313
Keywords
postprandial glycemic control1-deoxynojirimycinmulberry leaf aqueous extract
Publisher
MARY ANN LIEBERT, INC
Indexed
SCI; SCIE; SCOPUS; KCI WOS
Abstract
This study was a randomized, double-blind placebo-controlled trial to assess the efficacy of 4 weeks of mulberry leaf aqueous extract (MLAE) supplementation (5 g/day) for postprandial glycemic control in 36 subjects with impaired fasting glucose (IFG) tolerance. Postprandial responses in the glucose, insulin, and C-peptide levels were measured after a carbohydrate load both at baseline and after 4 weeks of MLAE supplementation. The postprandial glycemic response was attenuated in the MLAE group after the treatment period, particularly 30 and 60 min after loading (P=.003 and 0.0325 for glucose, P=.0005 and .0350 for insulin, and P=.0151 and .0864 for C-peptide). Additionally, the incremental area under the curve for insulin was significantly lower in the MLAE group than in the placebo group (P=.0207). Four weeks of MLAE supplementation improved postprandial glycemic control in individuals with IFG tolerance.
DOI
10.1089/jmf.2014.3160
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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