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Mulberry Leaf Extract Improves Postprandial Glucose Response in Prediabetic Subjects: A Randomized, Double-Blind Placebo-Controlled Trial
- Mulberry Leaf Extract Improves Postprandial Glucose Response in Prediabetic Subjects: A Randomized, Double-Blind Placebo-Controlled Trial
- Kim, Ji Yeon; Ok, Hyang Mok; Kim, Joohee; Park, Seok Won; Kwon, Sung Won; Kwon, Oran
- Ewha Authors
- 권오란; 김주희
- SCOPUS Author ID
- 권오란; 김주희
- Issue Date
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- 1096-620X; 1557-7600
- vol. 18, no. 3, pp. 306 - 313
- postprandial glycemic control; 1-deoxynojirimycin; mulberry leaf aqueous extract
- MARY ANN LIEBERT, INC
- SCI; SCIE; SCOPUS; KCI
- This study was a randomized, double-blind placebo-controlled trial to assess the efficacy of 4 weeks of mulberry leaf aqueous extract (MLAE) supplementation (5 g/day) for postprandial glycemic control in 36 subjects with impaired fasting glucose (IFG) tolerance. Postprandial responses in the glucose, insulin, and C-peptide levels were measured after a carbohydrate load both at baseline and after 4 weeks of MLAE supplementation. The postprandial glycemic response was attenuated in the MLAE group after the treatment period, particularly 30 and 60 min after loading (P=.003 and 0.0325 for glucose, P=.0005 and .0350 for insulin, and P=.0151 and .0864 for C-peptide). Additionally, the incremental area under the curve for insulin was significantly lower in the MLAE group than in the placebo group (P=.0207). Four weeks of MLAE supplementation improved postprandial glycemic control in individuals with IFG tolerance.
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