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Carbohydrate Intake Interacts With SNP276G > T Polymorphism in the Adiponectin Gene to Affect Fasting Blood Glucose, HbA1C, and HDL Cholesterol in Korean Patients With Type 2 Diabetes

Title
Carbohydrate Intake Interacts With SNP276G > T Polymorphism in the Adiponectin Gene to Affect Fasting Blood Glucose, HbA1C, and HDL Cholesterol in Korean Patients With Type 2 Diabetes
Authors
Hwang, Ji-YunPark, Ji EunChoi, Young JuHuh, Kap BumChang, NamsooKim, Wha Young
Ewha Authors
김화영장남수
SCOPUS Author ID
김화영scopus; 장남수scopus
Issue Date
2013
Journal Title
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
ISSN
0731-5724JCR Link
Citation
vol. 32, no. 3, pp. 143 - 150
Keywords
carbohydrateSNP 276gene-diet interactionglucose controltype 2 diabetes
Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Background/Objective: The SNP276G>T polymorphism in the adiponectin gene has been reported to be associated with type 2 diabetes and impaired glucose tolerance. The objective of this study was to examine whether SNP276G>T polymorphism influences the blood glucose levels in relation to dietary carbohydrate intake. Subjects/Methods: In an ongoing, prospective study, 673 patients with type 2 diabetes (339 men and 334 women, aged 40-85years) were recruited from one of two diabetes clinics in Seoul, Korea. The levels of carbohydrate intake were categorized as <55%, 55%-65%, and >65% of total energy intake. Results: Significant gene-nutrient interactions between SNP276G>T polymorphism and the level of carbohydrate intake were found, which modulated plasma fasting blood glucose (p = 0.0277), HbA1C (p = 0.0407), and high-density lipoprotein (HDL) cholesterol (p = 0.0134) concentrations. The G allele was associated with higher fasting blood glucose only in subjects consuming a low-carbohydrate diet (<55% of energy). However, when carbohydrate intake was intermediate (55%-65%), carriers of the T allele had greater fasting blood glucose and HbA1C concentrations. When carbohydrate intake was high (>65%), carriers of the T allele had greater HDL cholesterol concentrations. This interaction was significant even when carbohydrate intake was considered a continuous variable (p = 0.0200 for fasting blood glucose, p = 0.0408 for HbA1C, and p = 0.0254 for HDL cholesterol), suggesting a strong dose-response relation. Conclusions: Our data show that the effect of the SNP276G>T polymorphism on plasma fasting blood glucose, HbA1C, and HDL cholesterol concentrations depends on dietary carbohydrate intake.
DOI
10.1080/07315724.2013.791795
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신산업융합대학 > 식품영양학과 > Journal papers
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