Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김화영 | - |
dc.contributor.author | 장남수 | - |
dc.date.accessioned | 2016-08-27T02:08:36Z | - |
dc.date.available | 2016-08-27T02:08:36Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0731-5724 | - |
dc.identifier.other | OAK-10321 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/216750 | - |
dc.description.abstract | Background/Objective: The SNP276G>T polymorphism in the adiponectin gene has been reported to be associated with type 2 diabetes and impaired glucose tolerance. The objective of this study was to examine whether SNP276G>T polymorphism influences the blood glucose levels in relation to dietary carbohydrate intake. Subjects/Methods: In an ongoing, prospective study, 673 patients with type 2 diabetes (339 men and 334 women, aged 40-85years) were recruited from one of two diabetes clinics in Seoul, Korea. The levels of carbohydrate intake were categorized as <55%, 55%-65%, and >65% of total energy intake. Results: Significant gene-nutrient interactions between SNP276G>T polymorphism and the level of carbohydrate intake were found, which modulated plasma fasting blood glucose (p = 0.0277), HbA1C (p = 0.0407), and high-density lipoprotein (HDL) cholesterol (p = 0.0134) concentrations. The G allele was associated with higher fasting blood glucose only in subjects consuming a low-carbohydrate diet (<55% of energy). However, when carbohydrate intake was intermediate (55%-65%), carriers of the T allele had greater fasting blood glucose and HbA1C concentrations. When carbohydrate intake was high (>65%), carriers of the T allele had greater HDL cholesterol concentrations. This interaction was significant even when carbohydrate intake was considered a continuous variable (p = 0.0200 for fasting blood glucose, p = 0.0408 for HbA1C, and p = 0.0254 for HDL cholesterol), suggesting a strong dose-response relation. Conclusions: Our data show that the effect of the SNP276G>T polymorphism on plasma fasting blood glucose, HbA1C, and HDL cholesterol concentrations depends on dietary carbohydrate intake. | - |
dc.language | English | - |
dc.publisher | ROUTLEDGE JOURNALS, TAYLOR & | - |
dc.publisher | FRANCIS LTD | - |
dc.subject | carbohydrate | - |
dc.subject | SNP 276 | - |
dc.subject | gene-diet interaction | - |
dc.subject | glucose control | - |
dc.subject | type 2 diabetes | - |
dc.title | Carbohydrate Intake Interacts With SNP276G > T Polymorphism in the Adiponectin Gene to Affect Fasting Blood Glucose, HbA1C, and HDL Cholesterol in Korean Patients With Type 2 Diabetes | - |
dc.type | Article | - |
dc.relation.issue | 3 | - |
dc.relation.volume | 32 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 143 | - |
dc.relation.lastpage | 150 | - |
dc.relation.journaltitle | JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION | - |
dc.identifier.doi | 10.1080/07315724.2013.791795 | - |
dc.identifier.wosid | WOS:000322251500001 | - |
dc.author.google | Hwang, Ji-Yun | - |
dc.author.google | Park, Ji Eun | - |
dc.author.google | Choi, Young Ju | - |
dc.author.google | Huh, Kap Bum | - |
dc.author.google | Chang, Namsoo | - |
dc.author.google | Kim, Wha Young | - |
dc.contributor.scopusid | 김화영(35201071000;57213043374) | - |
dc.contributor.scopusid | 장남수(7202467832;56447965800) | - |
dc.date.modifydate | 20230502115030 | - |