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신산업융합대학
식품영양학과
Journal papers
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Function of NAD metabolism in white adipose tissue: lessons from mouse models
Title
Function of NAD metabolism in white adipose tissue: lessons from mouse models
Authors
Kwon
;
So Young
;
Park
;
Yoon Jung
Ewha Authors
박윤정
SCOPUS Author ID
박윤정
Issue Date
2024
Journal Title
Adipocyte
ISSN
2162-3945
Citation
Adipocyte vol. 13, no. 1
Keywords
NAD metabolism
;
NAD supplementation
;
Nicotinamide Adenine Dinucleotide
;
nicotinamide phosphoribosyltransferase
;
white adipose tissue
Publisher
Taylor and Francis Ltd.
Indexed
SCIE; SCOPUS
Document Type
Review
Abstract
Nicotinamide Adenine Dinucleotide (NAD) is an endogenous substance in redox reactions and regulates various functions in metabolism. NAD and its precursors are known for their anti-ageing and anti-obesity properties and are mainly active in the liver and muscle. Boosting NAD+ through supplementation with the precursors, such as nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), enhances insulin sensitivity and circadian rhythm in the liver, and improves mitochondrial function in the muscle. Recent evidence has revealed that the adipose tissue could be another direct target of NAD supplementation by attenuating inflammation and fat accumulation. Moreover, murine studies with genetically modified models demonstrated that nicotinamide phosphoribosyltransferase (NAMPT), a NAD regulatory enzyme that synthesizes NMN, played a critical role in lipogenesis and lipolysis in an adipocyte-specific manner. The tissue-specific effects of NAD+ metabolic pathways indicate a potential of the NAD precursors to control metabolic stress particularly via focusing on adipose tissue. Therefore, this narrative review raises an importance of NAD metabolism in white adipose tissue (WAT) through a variety of studies using different mouse models. © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
DOI
10.1080/21623945.2024.2313297
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