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신산업융합대학
식품영양학과
Journal papers
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Bone-Targeted Delivery of Cell-Penetrating-RUNX2 Fusion Protein in Osteoporosis Model
Title
Bone-Targeted Delivery of Cell-Penetrating-RUNX2 Fusion Protein in Osteoporosis Model
Authors
Kim
;
Seoyeon
;
Lee
;
Haein
;
Hong
;
Jiyeon
;
Seung Hyun L.
;
Kwon
;
Euntaek
;
Park
;
Tai Hyun
;
Hwang
;
Nathaniel S.
Ewha Authors
박태현
SCOPUS Author ID
박태현
Issue Date
2023
Journal Title
Advanced Science
ISSN
2198-3844
Citation
Advanced Science vol. 10, no. 28
Keywords
bone targeting
;
cell-penetrating protein
;
hydroxyapatite
;
osteogenic differentiation
;
osteoporosis
;
poly(aspartic acid)
Publisher
John Wiley and Sons Inc
Indexed
SCIE; SCOPUS
Document Type
Article
Abstract
The onset of osteoporosis leads to a gradual decrease in bone density due to an imbalance between bone formation and resorption. To achieve optimal drug efficacy with minimal side effects, targeted drug delivery to the bone is necessary. Previous studies have utilized peptides that bind to hydroxyapatite, a mineral component of bone, for bone-targeted drug delivery. In this study, a hydroxyapatite binding (HAB) tag is fused to 30Kc19α-Runt-related transcription factor 2 (RUNX2) for bone-targeting. This recombinant protein can penetrate the nucleus of human mesenchymal stem cells (hMSCs) and act as a master transcription factor for osteogenesis. The HAB tag increases the binding affinity of 30Kc19α-RUNX2 to mineral deposition in mature osteoblasts and bone tissue, without affecting its osteogenic induction capability. In the osteoporosis mouse model, intravenous injection of HAB-30Kc19α-RUNX2 results in preferential accumulation in the femur and promotes bone formation while reducing toxicity in the spleen. These findings suggest that HAB-30Kc19α-RUNX2 may be a promising candidate for bone-targeted therapy in osteoporosis. © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.
DOI
10.1002/advs.202301570
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