Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김양하 | * |
dc.date.accessioned | 2022-04-05T16:30:58Z | - |
dc.date.available | 2022-04-05T16:30:58Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 2072-6643 | * |
dc.identifier.other | OAK-27999 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261111 | - |
dc.description.abstract | Chrysanthemum (Chrysanthemum morifoliumRamat) flowers (CF) are widely consumed as herbal tea in many countries, including China. The aim of the present study was to examine the anti-adipogenic effect of hot water extraction of CF (HCF) on 3T3-L1 cells and their underlying cellular mechanisms. HCF treatment inhibited lipid accumulation under conditions that did not show the toxicity of 3T3-L1 adipocytes. The activity of glycerol-3-phosphate dehydrogenase (GPDH), which plays an important role in glycerol lipid metabolism, was also reduced by HCF. Adipogenesis/lipogenesis-related mRNA expression levels of peroxisome proliferator-activated receptor-gamma (PPAR-gamma), CCAAT/enhancer-binding protein-alpha (CEBP-alpha), sterol regulatory element-binding protein-1c (SREBP-1c), fatty acid-binding protein 4 (FABP4), acetyl-CoA carboxylase 1 (ACC1), and fatty acid synthase (FAS) were suppressed by HCF in a dose-dependent manner. Moreover, HCF increased activities of AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1), involved in lipid metabolism. These findings suggest that HCF inhibits adipocyte lipid accumulation through suppression of adipogenesis/lipogenesis-related gene expression and activation of the AMPK/SIRT1 pathway. Therefore, it suggests that HCF may be used as a potentially beneficial plant material for preventing obesity. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | Chrysanthemum morifoliumflower | * |
dc.subject | adipogenesis | * |
dc.subject | AMPK | * |
dc.subject | SIRT1 | * |
dc.title | Chrysanthemum morifoliumFlower Extract Inhibits Adipogenesis of 3T3-L1 Cells via AMPK/SIRT1 Pathway Activation | * |
dc.type | Article | * |
dc.relation.issue | 9 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | NUTRIENTS | * |
dc.identifier.doi | 10.3390/nu12092726 | * |
dc.identifier.wosid | WOS:000580110100001 | * |
dc.identifier.scopusid | 2-s2.0-85090238562 | * |
dc.author.google | Lee, Mak-Soon | * |
dc.author.google | Kim, Yangha | * |
dc.contributor.scopusid | 김양하(8524160300) | * |
dc.date.modifydate | 20240123090847 | * |