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Bacterial Outer Membrane Vesicles as Nano-Scale Bioreactors: A Fatty Acid Conversion Case Study

Title
Bacterial Outer Membrane Vesicles as Nano-Scale Bioreactors: A Fatty Acid Conversion Case Study
Authors
Song J.-W.Baeg Y.Jeong H.-Y.Lee J.Oh D.-K.Hollmann F.Park J.-B.
Ewha Authors
박진병
SCOPUS Author ID
박진병scopus
Issue Date
2021
Journal Title
ChemCatChem
ISSN
1867-3880JCR Link
Citation
ChemCatChem vol. 13, no. 19, pp. 4080 - 4086
Keywords
biocatalysisdecarboxylasehydratasenano-scale bioreactorouter membrane vesicles
Publisher
John Wiley and Sons Inc
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Bacterial outer membrane vesicles (OMVs) are small unilamellar proteoliposomes, involved in various functions including cell-to-cell signalling and protein excretion. We have engineered the OMVs of Escherichia coli to nano-scaled bioreactors for the biotransformation of fatty acids by targeting a fatty acid double bond hydratase of Stentrophomonas maltophilia (SmOhyA) and/or a photoactivated fatty acid decarboxylase from Chlorella variabilis NC64 A (CvFAP) into OMVs. Engineered OMVs containing both SmOhyA and CvFAP were able to catalyse the transformation of oleic acid ((Z)-octadec-9-enoic acid) into 9-hydroxyheptadecane via (R)-10-hydroxyoctadecanoic acid. The specific biotransformation rates of oleic acid reached 8.0×10−12 μmol/min per OMV. © 2021 The Authors. ChemCatChem published by Wiley-VCH GmbH
DOI
10.1002/cctc.202100778
Appears in Collections:
엘텍공과대학 > 식품공학전공 > Journal papers
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