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Azelaic Acid Promotes Caenorhabditis elegans Longevity at Low Temperature Via an Increase in Fatty Acid Desaturation
- Title
- Azelaic Acid Promotes Caenorhabditis elegans Longevity at Low Temperature Via an Increase in Fatty Acid Desaturation
- Authors
- Bai, Juan; Farias-Pereira, Renalison; Jang, Miran; Zhang, Yuan; Lee, Sang Mi; Kim, Young-Suk; Park, Yeonhwa; Ahn, Jun Bae; Kim, Gun-Hee; Kim, Kee-Hong
- Ewha Authors
- 김영석; 이상미
- SCOPUS Author ID
- 김영석; 이상미
- Issue Date
- 2021
- Journal Title
- PHARMACEUTICAL RESEARCH
- ISSN
- 0724-8741
1573-904X
- Citation
- PHARMACEUTICAL RESEARCH vol. 38, no. 1, pp. 15 - 26
- Keywords
- azelaic acid; C. elegans; fatty acid desaturation; lifespan
- Publisher
- SPRINGER/PLENUM PUBLISHERS
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Purpose Azelaic acid (AzA) is a dicarboxylic acid naturally occurring in various grains having anti-inflammatory and anti-oxidation properties. Recently, AzA is shown to reduce high-fat diet-induced adiposity in animals. However, its physiological role in lipid metabolism and aging in various environmental stresses is unknown. Methods and Results Using C. elegans as an invertebrate animal model, we demonstrate that AzA suppresses fat accumulation with no effect on lifespan at normal temperatures. Moreover, AzA promotes lifespan at low temperatures by elevation of unsaturated long-chain fatty acids and expression of genes in fatty acid desaturation. We further find that genes encoding fatty acid desaturases such as fat-1, fat-5, fat-6, and fat-7 are crucial for the lifespan-extending effect of AzA at low temperature. Conclusions Taken together, our results suggest that AzA promotes adaption to low temperature in C. elegans via shifting fatty acid profile to unsaturated long-chain fatty acids.
- DOI
- 10.1007/s11095-020-02975-w
- Appears in Collections:
- 공과대학 > 식품생명공학과 > Journal papers
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