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Azelaic Acid Promotes Caenorhabditis elegans Longevity at Low Temperature Via an Increase in Fatty Acid Desaturation

Title
Azelaic Acid Promotes Caenorhabditis elegans Longevity at Low Temperature Via an Increase in Fatty Acid Desaturation
Authors
Bai, JuanFarias-Pereira, RenalisonJang, MiranZhang, YuanLee, Sang MiKim, Young-SukPark, YeonhwaAhn, Jun BaeKim, Gun-HeeKim, Kee-Hong
Ewha Authors
김영석이상미
SCOPUS Author ID
김영석scopus; 이상미scopus
Issue Date
2021
Journal Title
PHARMACEUTICAL RESEARCH
ISSN
0724-8741JCR Link

1573-904XJCR Link
Citation
PHARMACEUTICAL RESEARCH vol. 38, no. 1, pp. 15 - 26
Keywords
azelaic acidC. elegansfatty acid desaturationlifespan
Publisher
SPRINGER/PLENUM PUBLISHERS
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Purpose Azelaic acid (AzA) is a dicarboxylic acid naturally occurring in various grains having anti-inflammatory and anti-oxidation properties. Recently, AzA is shown to reduce high-fat diet-induced adiposity in animals. However, its physiological role in lipid metabolism and aging in various environmental stresses is unknown. Methods and Results Using C. elegans as an invertebrate animal model, we demonstrate that AzA suppresses fat accumulation with no effect on lifespan at normal temperatures. Moreover, AzA promotes lifespan at low temperatures by elevation of unsaturated long-chain fatty acids and expression of genes in fatty acid desaturation. We further find that genes encoding fatty acid desaturases such as fat-1, fat-5, fat-6, and fat-7 are crucial for the lifespan-extending effect of AzA at low temperature. Conclusions Taken together, our results suggest that AzA promotes adaption to low temperature in C. elegans via shifting fatty acid profile to unsaturated long-chain fatty acids.
DOI
10.1007/s11095-020-02975-w
Appears in Collections:
엘텍공과대학 > 식품공학전공 > Journal papers
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