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The Anticancer Effect of Natural Plant Alkaloid Isoquinolines

Title
The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
Authors
Yun, DahyeYoon, So YoungPark, Soo JungPark, Yoon Jung
Ewha Authors
박윤정
SCOPUS Author ID
박윤정scopus
Issue Date
2021
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
1422-0067JCR Link
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol. 22, no. 4
Keywords
isoquinoline alkaloidsanticancercell cycle arrestapoptosisautophagyepigenetic regulation
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death. While the molecular mechanisms of these effects are not fully understood, it has been suggested that binding to nucleic acids or proteins, enzyme inhibition, and epigenetic modulation by isoquinoline alkaloids may play a role in the effects. This review discusses recent evidence on the molecular mechanisms by which the isoquinoline alkaloids can be a therapeutic target of cancer treatment.
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DOI
10.3390/ijms22041653
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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