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Jaceosidin ameliorates insulin resistance and kidney dysfunction by enhancing insulin receptor signaling and the antioxidant defense system in type 2 diabetic mice

Title
Jaceosidin ameliorates insulin resistance and kidney dysfunction by enhancing insulin receptor signaling and the antioxidant defense system in type 2 diabetic mice
Authors
Park E.Hong K.Kwon B.M.Kim Y.Kim J.-H.
Ewha Authors
김유리
SCOPUS Author ID
김유리scopusscopus
Issue Date
2020
Journal Title
Journal of Medicinal Food
ISSN
1096-620XJCR Link
Citation
Journal of Medicinal Food vol. 23, no. 10, pp. 1083 - 1092
Keywords
AktDiabetic nephropathyGlucose transporterJaceosidinSuperoxide dismutase
Publisher
Mary Ann Liebert Inc.
Indexed
SCIE; SCOPUS; KCI WOS scopus
Document Type
Article
Abstract
Emerging evidence has shown that flavonoids extracted from Artemisia have beneficial effects on metabolic disorders. However, whether and how jaceosidin ameliorates insulin resistance and diabetic nephropathy in type 2 diabetes mellitus is largely unknown. For 8 weeks, db/db diabetic mice were fed with or without jaceosidin. Oral jaceosidin supplementation reduced fasting blood glucose levels and insulin resistance through the upregulation of insulin receptor downstream pathways in the liver and skeletal muscles. While jaceosidin did not noticeably alter kidney filtration function, this dietary intervention contributed to attenuating the accumulation of advanced glycation end products in diabetic kidneys. The levels of VEGF-a (vascular endothelial growth factor-a) proteins in the diabetic kidneys were markedly diminished by jaceosidin treatments, which increased the expression and activity of Cu (copper) and Zn-SOD (zinc-superoxide dismutase). Therefore, it is suggested that jaceosidin supplementation elicits antidiabetic effects and treats diabetic nephropathy by augmenting insulin signaling, suppressing fibrosis, and enhancing antioxidant activity. © 2020 Mary Ann Liebert Inc.. All rights reserved.
DOI
10.1089/jmf.2020.4739
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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