View : 354 Download: 0

Walnut phenolic extract inhibits nuclear factor kappaB signaling in intestinal epithelial cells, and ameliorates experimental colitis and colitis-associated colon cancer in mice

Title
Walnut phenolic extract inhibits nuclear factor kappaB signaling in intestinal epithelial cells, and ameliorates experimental colitis and colitis-associated colon cancer in mice
Authors
Koh, Seong-JoonChoi, Youn-IKim, YuriKim, Yoo-SunChoi, Sang WoonKim, Ji WonKim, Byeong GwanLee, Kook Lae
Ewha Authors
김유리
SCOPUS Author ID
김유리scopus
Issue Date
2019
Journal Title
EUROPEAN JOURNAL OF NUTRITION
ISSN
1436-6207JCR Link

1436-6215JCR Link
Citation
EUROPEAN JOURNAL OF NUTRITION vol. 58, no. 4, pp. 1603 - 1613
Keywords
WalnutInflammatory bowel diseaseNuclear factor kappaBColon cancer
Publisher
SPRINGER HEIDELBERG
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
PurposeWalnuts (Juglans regia) are known to have anti-cancer and immunomodulatory effects. However, little information is available on the effects of walnut phenolic extract (WPE) on intestinal inflammation and colitis-associated colon cancer.MethodsCOLO205 cells were pretreated with WPE and then stimulated with tumor necrosis factor (TNF)-. In the acute colitis model, wild type mice (C57BL/6) were administered 4% dextran sulfate sodium (DSS) for 5 days. In the chronic colitis model, interleukin (IL)-10(-/-) mice were administered with either the vehicle or WPE (20mg/kg) by oral gavage daily for 2 weeks. In an inflammation-associated tumor model, wild type mice were administered a single intraperitoneal injection of azoxymethane followed by three cycles of 2% DSS for 5 days and 2 weeks of free water consumption.ResultsWPE significantly inhibited IL-8 and IL-1 expression in COLO205 cells. WPE attenuated both the TNF--induced IB phosphorylation/degradation and NF-B DNA binding activity. The administration of oral WPE significantly reduced the severity of colitis in both acute and chronic colitis models, including the IL-10(-/-) mice. In immunohistochemical staining, WPE attenuated NF-B signaling in the colons of both colitis models. Finally, WPE also significantly reduced tumor development in a murine model of colitis-associated colon cancer (CAC).ConclusionsWPE ameliorates acute and chronic colitis and CAC in mice, suggesting that WPE may have potentials for the treatment of inflammatory bowel disease.
Show the fulltext
DOI
10.1007/s00394-018-1704-3
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE