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Brain Microglial Activation in Chronic Pain-Associated Affective Disorder
- Title
- Brain Microglial Activation in Chronic Pain-Associated Affective Disorder
- Authors
- Barcelon, Ellane Eda; Choi, Woo-Hyun; Jun, Sang Beom; Lee, Sung Joong
- Ewha Authors
- 전상범
- SCOPUS Author ID
- 전상범
- Issue Date
- 2019
- Journal Title
- FRONTIERS IN NEUROSCIENCE
- ISSN
- 1662-453X
- Citation
- FRONTIERS IN NEUROSCIENCE vol. 13
- Keywords
- brain microglia; microglial activation; chronic pain; depression; TNF-alpha
- Publisher
- FRONTIERS MEDIA SA
- Indexed
- SCIE
- Document Type
- Article
- Abstract
- A growing body of evidence from both clinical and animal studies indicates that chronic neuropathic pain is associated with comorbid affective disorders. Spinal cord microglial activation is involved in nerve injury-induced pain hypersensitivity characterizing neuropathic pain. However, there is a lack of thorough assessments of microglial activation in the brain after nerve injury. In the present study, we characterized microglial activation in brain sub-regions of CX3CR1(GFP/+) mice after chronic constriction injury (CCI) of the sciatic nerve, including observations at delayed time points when affective brain dysfunctions such as depressive-like behaviors typically develop. Mice manifested chronic mechanical hypersensitivity immediately after CCI and developed depressive-like behaviors 8 weeks post-injury. Concurrently, significant increases of soma size and microglial cell number were observed in the medial prefrontal cortex (mPFC), hippocampus, and amygdala 8 weeks post-injury. Transcripts of CD11b, and TNF-alpha, genes associated with microglial activation or depressive-like behaviors, are correspondingly upregulated in these brain areas. Our results demonstrate that microglia are activated in specific brain sub-regions after CCI at delayed time points and imply that brain microglial activation plays a role in chronic pain-associated affective disorders.
- DOI
- 10.3389/fnins.2019.00213
- Appears in Collections:
- 공과대학 > 전자전기공학전공 > Journal papers
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