Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 전상범 | * |
dc.date.accessioned | 2019-04-16T16:30:12Z | - |
dc.date.available | 2019-04-16T16:30:12Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1662-453X | * |
dc.identifier.other | OAK-24587 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/249634 | - |
dc.description.abstract | A growing body of evidence from both clinical and animal studies indicates that chronic neuropathic pain is associated with comorbid affective disorders. Spinal cord microglial activation is involved in nerve injury-induced pain hypersensitivity characterizing neuropathic pain. However, there is a lack of thorough assessments of microglial activation in the brain after nerve injury. In the present study, we characterized microglial activation in brain sub-regions of CX3CR1(GFP/+) mice after chronic constriction injury (CCI) of the sciatic nerve, including observations at delayed time points when affective brain dysfunctions such as depressive-like behaviors typically develop. Mice manifested chronic mechanical hypersensitivity immediately after CCI and developed depressive-like behaviors 8 weeks post-injury. Concurrently, significant increases of soma size and microglial cell number were observed in the medial prefrontal cortex (mPFC), hippocampus, and amygdala 8 weeks post-injury. Transcripts of CD11b, and TNF-alpha, genes associated with microglial activation or depressive-like behaviors, are correspondingly upregulated in these brain areas. Our results demonstrate that microglia are activated in specific brain sub-regions after CCI at delayed time points and imply that brain microglial activation plays a role in chronic pain-associated affective disorders. | * |
dc.language | English | * |
dc.publisher | FRONTIERS MEDIA SA | * |
dc.subject | brain microglia | * |
dc.subject | microglial activation | * |
dc.subject | chronic pain | * |
dc.subject | depression | * |
dc.subject | TNF-alpha | * |
dc.title | Brain Microglial Activation in Chronic Pain-Associated Affective Disorder | * |
dc.type | Article | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.journaltitle | FRONTIERS IN NEUROSCIENCE | * |
dc.identifier.doi | 10.3389/fnins.2019.00213 | * |
dc.identifier.wosid | WOS:000461622300001 | * |
dc.author.google | Barcelon, Ellane Eda | * |
dc.author.google | Choi, Woo-Hyun | * |
dc.author.google | Jun, Sang Beom | * |
dc.author.google | Lee, Sung Joong | * |
dc.contributor.scopusid | 전상범(15843339100) | * |
dc.date.modifydate | 20240322125603 | * |