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Dietary wolfberry extract modifies oxidative stress by controlling the expression of inflammatory mrnas in overweight and hypercholesterolemic subjects: A randomized, double-blind, placebo-controlled trial
- Title
- Dietary wolfberry extract modifies oxidative stress by controlling the expression of inflammatory mrnas in overweight and hypercholesterolemic subjects: A randomized, double-blind, placebo-controlled trial
- Authors
- Lee Y.J.; Ahn Y.; Kwon O.; Lee M.Y.; Lee C.H.; Lee S.; Park T.; Kwon S.W.; Kim J.Y.
- Ewha Authors
- 권오란
- SCOPUS Author ID
- 권오란
- Issue Date
- 2017
- Journal Title
- Journal of Agricultural and Food Chemistry
- ISSN
- 0021-8561
- Citation
- Journal of Agricultural and Food Chemistry vol. 65, no. 2, pp. 309 - 316
- Keywords
- DNA damage; Inflammation; mRNA array; Postprandial inflammatory response; Wolfberry fruit extract
- Publisher
- American Chemical Society
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- In the present study, we evaluated the antioxidative and anti-inflammatory effects of an aqueous extract of wolfberry fruit (WBE) in mild hypercholesterolemic and overweight subjects. This study was a double-blind randomized trial of two parallel groups of free-living subjects (n = 53). The participants consumed the contents of an 80 mL pouch containing 13.5 g WBE or placebo after one meal per day over an 8-week period. Following 8 weeks of WBE supplementation, we observed a slight but significant decrease in erythrocyte superoxide dismutase activity and an increase in catalase activity. Furthermore, to assess endogenous DNA damage in lymphocytes, the alkaline comet assay was performed, showing that the percentage of DNA in the tail was significantly decreased by 8-week WBE intake. Additionally, the proportion of significantly deregulated mRNAs related to oxidative or inflammatory stress was considerably higher in the WBE intake group. The present data indicate that WBE intake has antioxidative and anti-inflammatory effects in overweight and hypercholesterolemic subjects by modulating mRNA expression. © 2016 American Chemical Society.
- DOI
- 10.1021/acs.jafc.6b04701
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
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