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dc.contributor.author이진규-
dc.date.accessioned2016-08-29T12:08:57Z-
dc.date.available2016-08-29T12:08:57Z-
dc.date.issued2016-
dc.identifier.issn1433-7851-
dc.identifier.issn1521-3773-
dc.identifier.otherOAK-16407-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/231050-
dc.description.abstractThe membrane-proximal external region (MPER) of HIV gp41 is an established target of antibodies that neutralize a broad range of HIV isolates. To evaluate the role of the transmembrane (TM) domain, synthetic MPER-derived peptides were incorporated into lipid nanoparticles using natural and designed TM domains, and antibody affinity was measured using immobilized and solution-based techniques. Peptides incorporating the native HIV TM domain exhibit significantly stronger interactions with neutralizing antibodies than peptides with a monomeric TM domain. Furthermore, a peptide with a trimeric, three-helix bundle TM domain recapitulates the binding profile of the native sequence. These studies suggest that neutralizing antibodies can bind the MPER when the TM domain is a three-helix bundle and this presentation could influence the binding of neutralizing antibodies to the virus. Lipid-bilayer presentation of viral antigens in Nanodiscs is a new platform for evaluating neutralizing antibodies.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectantibodies-
dc.subjectHIV-
dc.subjectmembrane proteins-
dc.subjectnanostructures-
dc.subjectpeptides-
dc.titleTrimerization of the HIV Transmembrane Domain in Lipid Bilayers Modulates Broadly Neutralizing Antibody Binding-
dc.typeArticle-
dc.relation.issue8-
dc.relation.volume55-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage2688-
dc.relation.lastpage2692-
dc.relation.journaltitleANGEWANDTE CHEMIE-INTERNATIONAL EDITION-
dc.identifier.doi10.1002/anie.201508421-
dc.identifier.wosidWOS:000370655700006-
dc.identifier.scopusid2-s2.0-84956868589-
dc.author.googleReichart, Timothy M.-
dc.author.googleBaksh, Michael M.-
dc.author.googleRhee, Jin-Kytt-
dc.author.googleFiedler, Jason D.-
dc.author.googleSligar, Stephen. G.-
dc.author.googleFinn, M. G.-
dc.author.googleZwick, Michael B.-
dc.author.googleDawson, Philip E.-
dc.contributor.scopusid이진규(56599780300)-
dc.date.modifydate20210915103222-
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엘텍공과대학 > 식품공학전공 > Journal papers
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