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dc.contributor.author김영석-
dc.date.accessioned2016-08-29T12:08:14Z-
dc.date.available2016-08-29T12:08:14Z-
dc.date.issued2015-
dc.identifier.issn9168-8451-
dc.identifier.otherOAK-15159-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/230648-
dc.description.abstractβ-Thujaplicin, one of the major constituents in Chamaecyparis obtusa, has been demonstrated to exert different health beneficial efficacy, but the role of β-thujaplicin in regulating mammary tumorigene-sis has not been investigated. In this study, we found that β-thujaplicin significantly suppressed the proliferation through arresting the cell cycle transition from G1 to S phase as well as inhibited the expression of cell cycle-related proteins, cyclin D1, and cyclin-dependent kinase 4 (CDK4) in MCF-7 and T47D luminal subtype breast cancer cells. In addition, estrogen receptor α (ER-α) was down-regulated by β-thujaplicin via enhanced proteolysis by ubiqui-tination, which led to cell growth inhibition. These results suggest that β-thujaplicin may be considered as a potent agent regulating the hormone sensitive mammary tumorigenesis. © 2015 Japan Society for Bioscience, Biotechnology, and Agrochemistry.-
dc.languageEnglish-
dc.publisherJapan Society for Bioscience Biotechnology and Agrochemistry-
dc.subjectBreast cancer-
dc.subjectCyclin D1-
dc.subjectEstrogen receptor-
dc.subjectUbiquitination-
dc.subjectβ-thujaplicin-
dc.titleβ-Thujaplicin modulates estrogen receptor signaling and inhibits proliferation of human breast cancer cells-
dc.typeArticle-
dc.relation.issue6-
dc.relation.volume79-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1011-
dc.relation.lastpage1017-
dc.relation.journaltitleBioscience, Biotechnology and Biochemistry-
dc.identifier.doi10.1080/09168451.2015.1008978-
dc.identifier.wosidWOS:000356239400021-
dc.identifier.scopusid2-s2.0-84940093475-
dc.author.googleKo J.-
dc.author.googleBao C.-
dc.author.googlePark H.-C.-
dc.author.googleKim M.-
dc.author.googleChoi H.-K.-
dc.author.googleKim Y.-S.-
dc.author.googleLee H.J.-
dc.contributor.scopusid김영석(56155360400)-
dc.date.modifydate20210929135933-
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엘텍공과대학 > 식품공학전공 > Journal papers
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