View : 622 Download: 0
Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A
- Title
- Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A
- Authors
- Arab, Khelifa; Park, Yoon Jung; Lindroth, Anders M.; Schaefer, Andrea; Oakes, Christopher; Weichenhan, Dieter; Lukanova, Annekatrin; Lundin, Eva; Risch, Angela; Meister, Michael; Dienemann, Hendrik; Dyckhoff, Gerhard; Herold-Mende, Christel; Grummt, Ingrid; Niehrs, Christof; Plass, Christoph
- Ewha Authors
- 박윤정
- SCOPUS Author ID
- 박윤정
- Issue Date
- 2014
- Journal Title
- MOLECULAR CELL
- ISSN
- 1097-2765
1097-4164
- Citation
- MOLECULAR CELL vol. 55, no. 4, pp. 604 - 614
- Publisher
- CELL PRESS
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- DNA methylation is a dynamic and reversible process that governs gene expression during development and disease. Several examples of active DNA demethylation have been documented, involving genome-wide and gene-specific DNA demethylation. How demethylating enzymes are targeted to specific genomic loci remains largely unknown. We show that an antisense lncRNA, termed TARID (for TCF21 antisense RNA inducing demethylation), activates TCF21 expression by inducing promoter demethylation. TARID interacts with both the TCF21 promoter and GADD45A (growth arrest and DNA-damage-inducible, alpha), a regulator of DNA demethylation. GADD45A in turn recruits thymine-DNA glycosylase for base excision repair-mediated demethylation involving oxidation of 5-methylcytosine to 5-hydroxymethylcytosine in the TCF21 promoter by ten-eleven translocation methylcytosine dioxygenase proteins. The results reveal a function of lncRNAs, serving as a genomic address label for GADD45A-mediated demethylation of specific target genes.
- DOI
- 10.1016/j.molcel.2014.06.031
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML