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dc.contributor.author박진병*
dc.contributor.author권용억*
dc.date.accessioned2016-08-27T04:08:55Z-
dc.date.available2016-08-27T04:08:55Z-
dc.date.issued2016*
dc.identifier.issn1463-9262*
dc.identifier.issn1463-9270*
dc.identifier.otherOAK-16504*
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/218053-
dc.description.abstractA practical chemoenzymatic synthetic method for 11-hydroxyundecanoic acid and 1,11-undecanedioic acid from ricinoleic acid (12-hydroxyoleic acid) was investigated. Biotransformation of ricinoleic acid into the ester (3) via 12-ketooleic acid (2) was driven by recombinant Escherichia coli cells expressing an alcohol dehydrogenase from Micrococcus luteus and the Baeyer-Villiger monooxygenase from Pseudomonas putida KT2440. The carbon-carbon double bond of the ester (3) was chemically reduced, and the ester bond was hydrolyzed to afford n-heptanoic acid (5) and 11-hydroxyundecanoic acid (7), which were converted into other related derivatives. For example, 11-hydroxyundecanoic acid was transformed into 1,11-undecanedioic acid (8) under fairly mild reaction conditions. Whole-cell biotransformation at high cell density (i.e., 20 g dry cells per L) allowed the final ester product concentration and volumetric productivity to reach 53 mM and 6.6 mM h(-1), respectively. The overall molar yield of 1,11-undecanedioic acid from ricinoleic acid was 55% based on the biotransformation and chemical transformation conversion yields of 84% and 65%, respectively.*
dc.languageEnglish*
dc.publisherROYAL SOC CHEMISTRY*
dc.titleChemo-enzymatic synthesis of 11-hydroxyundecanoic acid and 1,11-undecanedioic acid from ricinoleic acid*
dc.typeArticle*
dc.relation.issue4*
dc.relation.volume18*
dc.relation.indexSCI*
dc.relation.indexSCIE*
dc.relation.indexSCOPUS*
dc.relation.startpage1089*
dc.relation.lastpage1095*
dc.relation.journaltitleGREEN CHEMISTRY*
dc.identifier.doi10.1039/c5gc01017a*
dc.identifier.wosidWOS:000370617600025*
dc.author.googleJang, Hyun-Young*
dc.author.googleSingha, Kaushik*
dc.author.googleKim, Hwan-Hee*
dc.author.googleKwon, Yong-Uk*
dc.author.googlePark, Jin-Byung*
dc.contributor.scopusid박진병(15036390700)*
dc.contributor.scopusid권용억(7403459303)*
dc.date.modifydate20240123110347*
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엘텍공과대학 > 식품공학전공 > Journal papers
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