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dc.contributor.author박진병-
dc.contributor.author권용억-
dc.date.accessioned2016-08-27T04:08:55Z-
dc.date.available2016-08-27T04:08:55Z-
dc.date.issued2016-
dc.identifier.issn1463-9262-
dc.identifier.issn1463-9270-
dc.identifier.otherOAK-16504-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/218053-
dc.description.abstractA practical chemoenzymatic synthetic method for 11-hydroxyundecanoic acid and 1,11-undecanedioic acid from ricinoleic acid (12-hydroxyoleic acid) was investigated. Biotransformation of ricinoleic acid into the ester (3) via 12-ketooleic acid (2) was driven by recombinant Escherichia coli cells expressing an alcohol dehydrogenase from Micrococcus luteus and the Baeyer-Villiger monooxygenase from Pseudomonas putida KT2440. The carbon-carbon double bond of the ester (3) was chemically reduced, and the ester bond was hydrolyzed to afford n-heptanoic acid (5) and 11-hydroxyundecanoic acid (7), which were converted into other related derivatives. For example, 11-hydroxyundecanoic acid was transformed into 1,11-undecanedioic acid (8) under fairly mild reaction conditions. Whole-cell biotransformation at high cell density (i.e., 20 g dry cells per L) allowed the final ester product concentration and volumetric productivity to reach 53 mM and 6.6 mM h(-1), respectively. The overall molar yield of 1,11-undecanedioic acid from ricinoleic acid was 55% based on the biotransformation and chemical transformation conversion yields of 84% and 65%, respectively.-
dc.languageEnglish-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleChemo-enzymatic synthesis of 11-hydroxyundecanoic acid and 1,11-undecanedioic acid from ricinoleic acid-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume18-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1089-
dc.relation.lastpage1095-
dc.relation.journaltitleGREEN CHEMISTRY-
dc.identifier.doi10.1039/c5gc01017a-
dc.identifier.wosidWOS:000370617600025-
dc.author.googleJang, Hyun-Young-
dc.author.googleSingha, Kaushik-
dc.author.googleKim, Hwan-Hee-
dc.author.googleKwon, Yong-Uk-
dc.author.googlePark, Jin-Byung-
dc.contributor.scopusid박진병(15036390700)-
dc.contributor.scopusid권용억(7403459303)-
dc.date.modifydate20210929144247-
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엘텍공과대학 > 식품공학전공 > Journal papers
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