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dc.contributor.author김화영-
dc.contributor.author장남수-
dc.date.accessioned2016-08-27T02:08:36Z-
dc.date.available2016-08-27T02:08:36Z-
dc.date.issued2013-
dc.identifier.issn0731-5724-
dc.identifier.otherOAK-10321-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/216750-
dc.description.abstractBackground/Objective: The SNP276G>T polymorphism in the adiponectin gene has been reported to be associated with type 2 diabetes and impaired glucose tolerance. The objective of this study was to examine whether SNP276G>T polymorphism influences the blood glucose levels in relation to dietary carbohydrate intake. Subjects/Methods: In an ongoing, prospective study, 673 patients with type 2 diabetes (339 men and 334 women, aged 40-85years) were recruited from one of two diabetes clinics in Seoul, Korea. The levels of carbohydrate intake were categorized as <55%, 55%-65%, and >65% of total energy intake. Results: Significant gene-nutrient interactions between SNP276G>T polymorphism and the level of carbohydrate intake were found, which modulated plasma fasting blood glucose (p = 0.0277), HbA1C (p = 0.0407), and high-density lipoprotein (HDL) cholesterol (p = 0.0134) concentrations. The G allele was associated with higher fasting blood glucose only in subjects consuming a low-carbohydrate diet (<55% of energy). However, when carbohydrate intake was intermediate (55%-65%), carriers of the T allele had greater fasting blood glucose and HbA1C concentrations. When carbohydrate intake was high (>65%), carriers of the T allele had greater HDL cholesterol concentrations. This interaction was significant even when carbohydrate intake was considered a continuous variable (p = 0.0200 for fasting blood glucose, p = 0.0408 for HbA1C, and p = 0.0254 for HDL cholesterol), suggesting a strong dose-response relation. Conclusions: Our data show that the effect of the SNP276G>T polymorphism on plasma fasting blood glucose, HbA1C, and HDL cholesterol concentrations depends on dietary carbohydrate intake.-
dc.languageEnglish-
dc.publisherROUTLEDGE JOURNALS, TAYLOR &amp-
dc.publisherFRANCIS LTD-
dc.subjectcarbohydrate-
dc.subjectSNP 276-
dc.subjectgene-diet interaction-
dc.subjectglucose control-
dc.subjecttype 2 diabetes-
dc.titleCarbohydrate Intake Interacts With SNP276G > T Polymorphism in the Adiponectin Gene to Affect Fasting Blood Glucose, HbA1C, and HDL Cholesterol in Korean Patients With Type 2 Diabetes-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume32-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage143-
dc.relation.lastpage150-
dc.relation.journaltitleJOURNAL OF THE AMERICAN COLLEGE OF NUTRITION-
dc.identifier.doi10.1080/07315724.2013.791795-
dc.identifier.wosidWOS:000322251500001-
dc.author.googleHwang, Ji-Yun-
dc.author.googlePark, Ji Eun-
dc.author.googleChoi, Young Ju-
dc.author.googleHuh, Kap Bum-
dc.author.googleChang, Namsoo-
dc.author.googleKim, Wha Young-
dc.contributor.scopusid김화영(35201071000)-
dc.contributor.scopusid장남수(7202467832)-
dc.date.modifydate20180104081001-
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신산업융합대학 > 식품영양학과 > Journal papers
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