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Folate nutrition is related to neuropsychological functions in the elderly

Title
Folate nutrition is related to neuropsychological functions in the elderly
Authors
Chang, NamsooKim, EunJungKim, Ki NamKim, HyesookKim, Seong YoonJeong, Bum Seok
Ewha Authors
장남수김기남김혜숙
SCOPUS Author ID
장남수scopusscopus; 김기남scopus; 김혜숙scopusscopus
Issue Date
2009
Journal Title
NUTRITION RESEARCH AND PRACTICE
ISSN
1976-1457JCR Link
Citation
NUTRITION RESEARCH AND PRACTICE vol. 3, no. 1, pp. 43 - 48
Keywords
FolateB vitaminsneuropsychological functionelderly
Publisher
KOREAN NUTRITION SOC
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
We investigated the nutritional state of B vitamins and the neuropsychological functions in 25 subjects, aged 63.1 +/- 6.3 years, residing in rural areas of Korea. Nutritional states of thiamin, riboflavin. and pyridoxine were assessed enzymatically in the erythrocytes, and folate concentrations were measured microbiologically in the plasma and erythrocytes. A battery of composite neuropsychological test was administered to the subjects. Plasma folate was correlated with the total intelligence score (p=0.049). Folate levels in the erythrocytes were correlated with the performance intelligence scores such as block design (p=0.017) and picture arrangement (p=0.016). The red cell folate was correlated with memory scores such as general memory (p=0.009) and delayed recall (p=0.000). Although it did not reach statistical significance, verbal memory (p=0.053) was highly correlated with the red cell folate. The red cell folate was also correlated positively with the percent of conceptual level response number score (p=0.029), and negatively with the grooved pegboard test score for the non-dominant hand (p=0.010). Fine motor coordination was also influenced by folate nutrition, as finger tapping scores in both hands were significantly correlated with red cell folate (dominant hand; p=0.026, non-dominant hand: p=0.004). Other B vitamins such as thiamin, riboflavin, and vitamin B(6) were not as strongly correlated with neuropsychological function test scores as folate was. These results Suggest that folate nutrition influences neuropsychological function test scores significantly in humans. Further studies arc needed to explore the relationship between folate or other vitamin B nutrition and neuropsychological functions and the implications thereof.
DOI
10.4162/nrp.2009.3.1.43
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
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