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Rational Design of Efficient Heavy-Atom-Free Boron-Dipyrromethene Nanophotosensitizers for Two-Photon Excited Photodynamic Therapy of Cancer
- Title
- Rational Design of Efficient Heavy-Atom-Free Boron-Dipyrromethene Nanophotosensitizers for Two-Photon Excited Photodynamic Therapy of Cancer
- Authors
- Nguyen; Van-Nghia; Lee; Dong Joon; Zhang; Dianqi; Ha; Jeongsun; Swamy; Kunemadihalli Mathada Kotraiah; Wang; Rui; Kim; Hwan Myung; Yu; Fabiao; Yoon; Juyoung
- Ewha Authors
- 윤주영; K.M.K. Swamy; Nguyen Van Nghia
- SCOPUS Author ID
- 윤주영; Nguyen Van Nghia
- Issue Date
- 2024
- Journal Title
- Chemistry of Materials
- ISSN
- 8974-4756
- Citation
- Chemistry of Materials vol. 36, no. 11, pp. 5534 - 5541
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Although boron-dipyrromethene (BODIPY) dyes have been widely recognized for their potential use as photosensitizers (PSs) in cancer treatment, the development of heavy-atom-free BODIPY PSs for photodynamic therapy (PDT), particularly in two-photon excited photodynamic therapy (2PE-PDT), remains challenging. Herein, a novel heavy-atom-free photosensitizer (BDP-6) with optimized singlet-triplet energy gap and steric hindrance was designed and synthesized to facilitate intersystem crossing and improve fluorescence intensity. To enhance the biocompatibility and tumor-targeting ability of BDP-6, corresponding nanophotosensitizers (BDP-6 NPs) were prepared by encapsulating BDP-6 within DSPE-PEG(2000) biotin. Compared to control BDP-5 NPs without dimethyl groups, BDP-6 NPs exhibited brighter deep red fluorescence and higher efficiency in generating reactive oxygen species (ROS) under one-photon excitation in aqueous solutions. Moreover, BDP-6 NPs displayed excellent tumor-targeting ability, bright red emission, and considerable phototoxicity with low dark toxicity toward cancer cells. Notably, under two-photon excitation, the BDP-6 NPs efficiently generated ROS both in aqueous solutions and living cells, thereby demonstrating exceptional performance in 2PE-PDT for cancer cell ablation. Furthermore, in vivo experiments revealed that BDP-6 NPs hold great promise for cancer PDT. Our work presents practical strategies for developing tumor-targeting heavy-atom-free nanophotosensitizers based on BODIPY dye for 2PE-PDT of cancer. © 2024 American Chemical Society
- DOI
- 10.1021/acs.chemmater.4c00482
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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