Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 윤주영 | - |
dc.contributor.author | K.M.K. Swamy | - |
dc.contributor.author | Nguyen Van Nghia | - |
dc.date.accessioned | 2024-08-26T16:31:09Z | - |
dc.date.available | 2024-08-26T16:31:09Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 8974-4756 | - |
dc.identifier.other | OAK-35774 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/269367 | - |
dc.description.abstract | Although boron-dipyrromethene (BODIPY) dyes have been widely recognized for their potential use as photosensitizers (PSs) in cancer treatment, the development of heavy-atom-free BODIPY PSs for photodynamic therapy (PDT), particularly in two-photon excited photodynamic therapy (2PE-PDT), remains challenging. Herein, a novel heavy-atom-free photosensitizer (BDP-6) with optimized singlet-triplet energy gap and steric hindrance was designed and synthesized to facilitate intersystem crossing and improve fluorescence intensity. To enhance the biocompatibility and tumor-targeting ability of BDP-6, corresponding nanophotosensitizers (BDP-6 NPs) were prepared by encapsulating BDP-6 within DSPE-PEG(2000) biotin. Compared to control BDP-5 NPs without dimethyl groups, BDP-6 NPs exhibited brighter deep red fluorescence and higher efficiency in generating reactive oxygen species (ROS) under one-photon excitation in aqueous solutions. Moreover, BDP-6 NPs displayed excellent tumor-targeting ability, bright red emission, and considerable phototoxicity with low dark toxicity toward cancer cells. Notably, under two-photon excitation, the BDP-6 NPs efficiently generated ROS both in aqueous solutions and living cells, thereby demonstrating exceptional performance in 2PE-PDT for cancer cell ablation. Furthermore, in vivo experiments revealed that BDP-6 NPs hold great promise for cancer PDT. Our work presents practical strategies for developing tumor-targeting heavy-atom-free nanophotosensitizers based on BODIPY dye for 2PE-PDT of cancer. © 2024 American Chemical Society | - |
dc.description.sponsorship | American Chemical Society | - |
dc.language | English | - |
dc.title | Rational Design of Efficient Heavy-Atom-Free Boron-Dipyrromethene Nanophotosensitizers for Two-Photon Excited Photodynamic Therapy of Cancer | - |
dc.type | Article | - |
dc.relation.issue | 11 | - |
dc.relation.volume | 36 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 5534 | - |
dc.relation.lastpage | 5541 | - |
dc.relation.journaltitle | Chemistry of Materials | - |
dc.identifier.doi | 10.1021/acs.chemmater.4c00482 | - |
dc.identifier.wosid | WOS:001230241100001 | - |
dc.identifier.scopusid | 2-s2.0-85194235434 | - |
dc.author.google | Nguyen | - |
dc.author.google | Van-Nghia | - |
dc.author.google | Lee | - |
dc.author.google | Dong Joon | - |
dc.author.google | Zhang | - |
dc.author.google | Dianqi | - |
dc.author.google | Ha | - |
dc.author.google | Jeongsun | - |
dc.author.google | Swamy | - |
dc.author.google | Kunemadihalli Mathada Kotraiah | - |
dc.author.google | Wang | - |
dc.author.google | Rui | - |
dc.author.google | Kim | - |
dc.author.google | Hwan Myung | - |
dc.author.google | Yu | - |
dc.author.google | Fabiao | - |
dc.author.google | Yoon | - |
dc.author.google | Juyoung | - |
dc.contributor.scopusid | 윤주영(7403587371) | - |
dc.contributor.scopusid | Nguyen Van Nghia(57211275427) | - |
dc.date.modifydate | 20240826132715 | - |