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Pannorin isolated from marine Penicillium sp. SG-W3: a selective monoamine oxidase A inhibitor
- Title
- Pannorin isolated from marine Penicillium sp. SG-W3: a selective monoamine oxidase A inhibitor
- Authors
- Jong Min; Gao; Qian; Shin; Woong-Hee; Lee; Eun-Young; Chung; Dawoon; Choi; Oh; Grace; Nam; Sang-Jip; Kim; Hoon
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
![scopus](/images/layout/icon2.png)
- Issue Date
- 2024
- Journal Title
- Applied Biological Chemistry
- ISSN
- 2468-0834
- Citation
- Applied Biological Chemistry vol. 67, no. 1
- Keywords
- Enzyme kinetics; Molecular docking and dynamics; Monoamine oxidase; Pannorin; Penicillium sp. SG-W3; Reversible competitive inhibitor
- Publisher
- Springer Science and Business Media B.V.
- Indexed
- SCIE; SCOPUS; KCI
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- Six compounds were isolated from Penicillium sp. SG-W3, a marine-derived fungus, and their inhibitory activities against target enzymes relating to neurological diseases were evaluated. Compound 1 (pannorin) was a potent and selective monoamine oxidase (MAO)-A inhibitor with a 50% inhibitory concentration (IC50) of 1.734 μM and a selectivity index (SI) of > 23.07 versus MAO-B, and it showed an efficient antioxidant activity. All compounds showed weak inhibitory activities against acetylcholinesterase, butyrylcholinesterase, and β-secretase. The inhibition constant (Ki) of 1 for MAO-A was 1.049 ± 0.030 μM with competitive inhibition. Molecular docking simulation predicted that compound 1 forms hydrogen bonds with MAO-A, and binds more tightly to MAO-A than to MAO-B (− 25.02 and − 24.06 kcal/mol, respectively). These results suggest that compound 1 is a selective, reversible, and competitive MAO-A inhibitor that can be a therapeutic candidate for treating neurological diseases. © The Author(s) 2024.
- DOI
- 10.1186/s13765-024-00878-7
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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