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dc.contributor.author남상집-
dc.date.accessioned2024-05-20T16:31:03Z-
dc.date.available2024-05-20T16:31:03Z-
dc.date.issued2024-
dc.identifier.issn2468-0834-
dc.identifier.otherOAK-34943-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/268408-
dc.description.abstractSix compounds were isolated from Penicillium sp. SG-W3, a marine-derived fungus, and their inhibitory activities against target enzymes relating to neurological diseases were evaluated. Compound 1 (pannorin) was a potent and selective monoamine oxidase (MAO)-A inhibitor with a 50% inhibitory concentration (IC50) of 1.734 μM and a selectivity index (SI) of > 23.07 versus MAO-B, and it showed an efficient antioxidant activity. All compounds showed weak inhibitory activities against acetylcholinesterase, butyrylcholinesterase, and β-secretase. The inhibition constant (Ki) of 1 for MAO-A was 1.049 ± 0.030 μM with competitive inhibition. Molecular docking simulation predicted that compound 1 forms hydrogen bonds with MAO-A, and binds more tightly to MAO-A than to MAO-B (− 25.02 and − 24.06 kcal/mol, respectively). These results suggest that compound 1 is a selective, reversible, and competitive MAO-A inhibitor that can be a therapeutic candidate for treating neurological diseases. © The Author(s) 2024.-
dc.languageEnglish-
dc.publisherSpringer Science and Business Media B.V.-
dc.subjectEnzyme kinetics-
dc.subjectMolecular docking and dynamics-
dc.subjectMonoamine oxidase-
dc.subjectPannorin-
dc.subjectPenicillium sp. SG-W3-
dc.subjectReversible competitive inhibitor-
dc.titlePannorin isolated from marine Penicillium sp. SG-W3: a selective monoamine oxidase A inhibitor-
dc.typeArticle-
dc.relation.issue1-
dc.relation.volume67-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.journaltitleApplied Biological Chemistry-
dc.identifier.doi10.1186/s13765-024-00878-7-
dc.identifier.wosidWOS:001174161300001-
dc.identifier.scopusid2-s2.0-85186562699-
dc.author.googleJong Min-
dc.author.googleGao-
dc.author.googleQian-
dc.author.googleShin-
dc.author.googleWoong-Hee-
dc.author.googleLee-
dc.author.googleEun-Young-
dc.author.googleChung-
dc.author.googleDawoon-
dc.author.googleChoi-
dc.author.googleOh-
dc.author.googleGrace-
dc.author.googleNam-
dc.author.googleSang-Jip-
dc.author.googleKim-
dc.author.googleHoon-
dc.contributor.scopusid남상집(57208839798)-
dc.date.modifydate20240520113511-
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자연과학대학 > 화학·나노과학전공 > Journal papers
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