Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | - |
dc.date.accessioned | 2024-05-20T16:31:03Z | - |
dc.date.available | 2024-05-20T16:31:03Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 2468-0834 | - |
dc.identifier.other | OAK-34943 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/268408 | - |
dc.description.abstract | Six compounds were isolated from Penicillium sp. SG-W3, a marine-derived fungus, and their inhibitory activities against target enzymes relating to neurological diseases were evaluated. Compound 1 (pannorin) was a potent and selective monoamine oxidase (MAO)-A inhibitor with a 50% inhibitory concentration (IC50) of 1.734 μM and a selectivity index (SI) of > 23.07 versus MAO-B, and it showed an efficient antioxidant activity. All compounds showed weak inhibitory activities against acetylcholinesterase, butyrylcholinesterase, and β-secretase. The inhibition constant (Ki) of 1 for MAO-A was 1.049 ± 0.030 μM with competitive inhibition. Molecular docking simulation predicted that compound 1 forms hydrogen bonds with MAO-A, and binds more tightly to MAO-A than to MAO-B (− 25.02 and − 24.06 kcal/mol, respectively). These results suggest that compound 1 is a selective, reversible, and competitive MAO-A inhibitor that can be a therapeutic candidate for treating neurological diseases. © The Author(s) 2024. | - |
dc.language | English | - |
dc.publisher | Springer Science and Business Media B.V. | - |
dc.subject | Enzyme kinetics | - |
dc.subject | Molecular docking and dynamics | - |
dc.subject | Monoamine oxidase | - |
dc.subject | Pannorin | - |
dc.subject | Penicillium sp. SG-W3 | - |
dc.subject | Reversible competitive inhibitor | - |
dc.title | Pannorin isolated from marine Penicillium sp. SG-W3: a selective monoamine oxidase A inhibitor | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 67 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.journaltitle | Applied Biological Chemistry | - |
dc.identifier.doi | 10.1186/s13765-024-00878-7 | - |
dc.identifier.wosid | WOS:001174161300001 | - |
dc.identifier.scopusid | 2-s2.0-85186562699 | - |
dc.author.google | Jong Min | - |
dc.author.google | Gao | - |
dc.author.google | Qian | - |
dc.author.google | Shin | - |
dc.author.google | Woong-Hee | - |
dc.author.google | Lee | - |
dc.author.google | Eun-Young | - |
dc.author.google | Chung | - |
dc.author.google | Dawoon | - |
dc.author.google | Choi | - |
dc.author.google | Oh | - |
dc.author.google | Grace | - |
dc.author.google | Nam | - |
dc.author.google | Sang-Jip | - |
dc.author.google | Kim | - |
dc.author.google | Hoon | - |
dc.contributor.scopusid | 남상집(57208839798) | - |
dc.date.modifydate | 20240520113511 | - |