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Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells
- Title
- Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells
- Authors
- Yi; Park; So-Yeon; Hong; Ahreum; Kim; Jeong-Hyeon; Oh; Dong-Chan; Hangun; Nam; Sang-Jip; Kang; Heonjoong; Pulat; Sultan; Yang; Inho; Lee; Jihye; Hwang; Sunghoon; Zhou; Rui; Gamage; Chathurika D. B.; Varlı; Mücahit; Taş; İsa
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
![scopus](/images/layout/icon2.png)
- Issue Date
- 2024
- Journal Title
- Marine Drugs
- ISSN
- 1660-3397
- Citation
- Marine Drugs vol. 22, no. 2
- Keywords
- colorectal cancer; EMT; gastric cancer; lung cancer; marine natural products; MMP; Rho GTPases
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus 1, which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells. © 2024 by the authors.
- DOI
- 10.3390/md22020088
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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