Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | - |
dc.date.accessioned | 2024-05-20T16:31:02Z | - |
dc.date.available | 2024-05-20T16:31:02Z | - |
dc.date.issued | 2024 | - |
dc.identifier.issn | 1660-3397 | - |
dc.identifier.other | OAK-34951 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/268400 | - |
dc.description.abstract | Anithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus 1, which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells. © 2024 by the authors. | - |
dc.language | English | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.subject | colorectal cancer | - |
dc.subject | EMT | - |
dc.subject | gastric cancer | - |
dc.subject | lung cancer | - |
dc.subject | marine natural products | - |
dc.subject | MMP | - |
dc.subject | Rho GTPases | - |
dc.title | Anithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 22 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | Marine Drugs | - |
dc.identifier.doi | 10.3390/md22020088 | - |
dc.identifier.wosid | WOS:001175074000001 | - |
dc.identifier.scopusid | 2-s2.0-85185858219 | - |
dc.author.google | Yi | - |
dc.author.google | Park | - |
dc.author.google | So-Yeon | - |
dc.author.google | Hong | - |
dc.author.google | Ahreum | - |
dc.author.google | Kim | - |
dc.author.google | Jeong-Hyeon | - |
dc.author.google | Oh | - |
dc.author.google | Dong-Chan | - |
dc.author.google | Hangun | - |
dc.author.google | Nam | - |
dc.author.google | Sang-Jip | - |
dc.author.google | Kang | - |
dc.author.google | Heonjoong | - |
dc.author.google | Pulat | - |
dc.author.google | Sultan | - |
dc.author.google | Yang | - |
dc.author.google | Inho | - |
dc.author.google | Lee | - |
dc.author.google | Jihye | - |
dc.author.google | Hwang | - |
dc.author.google | Sunghoon | - |
dc.author.google | Zhou | - |
dc.author.google | Rui | - |
dc.author.google | Gamage | - |
dc.author.google | Chathurika D. B. | - |
dc.author.google | Varlı | - |
dc.author.google | Mücahit | - |
dc.author.google | Taş | - |
dc.author.google | İsa | - |
dc.contributor.scopusid | 남상집(57208839798) | - |
dc.date.modifydate | 20240520114812 | - |