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dc.contributor.author남상집-
dc.date.accessioned2024-05-20T16:31:02Z-
dc.date.available2024-05-20T16:31:02Z-
dc.date.issued2024-
dc.identifier.issn1660-3397-
dc.identifier.otherOAK-34951-
dc.identifier.urihttps://dspace.ewha.ac.kr/handle/2015.oak/268400-
dc.description.abstractAnithiactin D (1), a 2-phenylthiazole class of natural products, was isolated from marine mudflat-derived actinomycetes Streptomyces sp. 10A085. The chemical structure of 1 was elucidated based on the interpretation of NMR and MS data. The absolute configuration of 1 was determined by comparing the experimental and calculated electronic circular dichroism (ECD) spectral data. Anithiactin D (1) significantly decreased cancer cell migration and invasion activities at a concentration of 5 μM via downregulation of the epithelial-to-mesenchymal transition (EMT) markers in A549, AGS, and Caco-2 cell lines. Moreover, 1 inhibited the activity of Rho GTPases, including Rac1 and RhoA in the A549 cell line, suppressed RhoA in AGS and Caco-2 cell lines, and decreased the mRNA expression levels of some matrix metalloproteinases (MMPs) in AGS and Caco-2 cell lines. Thus 1, which is a new entity of the 2-phenylthiazole class of natural products with a unique aniline-indole fused moiety, is a potent inhibitor of the motility of cancer cells. © 2024 by the authors.-
dc.languageEnglish-
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)-
dc.subjectcolorectal cancer-
dc.subjectEMT-
dc.subjectgastric cancer-
dc.subjectlung cancer-
dc.subjectmarine natural products-
dc.subjectMMP-
dc.subjectRho GTPases-
dc.titleAnithiactin D, a Phenylthiazole Natural Product from Mudflat-Derived Streptomyces sp., Suppresses Motility of Cancer Cells-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume22-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.journaltitleMarine Drugs-
dc.identifier.doi10.3390/md22020088-
dc.identifier.wosidWOS:001175074000001-
dc.identifier.scopusid2-s2.0-85185858219-
dc.author.googleYi-
dc.author.googlePark-
dc.author.googleSo-Yeon-
dc.author.googleHong-
dc.author.googleAhreum-
dc.author.googleKim-
dc.author.googleJeong-Hyeon-
dc.author.googleOh-
dc.author.googleDong-Chan-
dc.author.googleHangun-
dc.author.googleNam-
dc.author.googleSang-Jip-
dc.author.googleKang-
dc.author.googleHeonjoong-
dc.author.googlePulat-
dc.author.googleSultan-
dc.author.googleYang-
dc.author.googleInho-
dc.author.googleLee-
dc.author.googleJihye-
dc.author.googleHwang-
dc.author.googleSunghoon-
dc.author.googleZhou-
dc.author.googleRui-
dc.author.googleGamage-
dc.author.googleChathurika D. B.-
dc.author.googleVarlı-
dc.author.googleMücahit-
dc.author.googleTaş-
dc.author.googleİsa-
dc.contributor.scopusid남상집(57208839798)-
dc.date.modifydate20240520114812-


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