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A combination of rebaudioside A and neohesperidin dihydrochalcone suppressed weight gain by regulating visceral fat and hepatic lipid metabolism in ob/ob mice
- Title
- A combination of rebaudioside A and neohesperidin dihydrochalcone suppressed weight gain by regulating visceral fat and hepatic lipid metabolism in ob/ob mice
- Authors
- Kim; Yeri; Han; Hyejin; Oh; Yeonsoo; Shin; Hakdong; Park; Gwoncheol; Sunghee; Manthey; John A.; Yang; Yuri
- Ewha Authors
- 김유리
- SCOPUS Author ID
- 김유리
- Issue Date
- 2024
- Journal Title
- Food Science and Biotechnology
- ISSN
- 1226-7708
- Citation
- Food Science and Biotechnology vol. 33, no. 4, pp. 913 - 923
- Keywords
- Metabolic diseases; Microbiota; Neohesperidin dihydrochalcone; Obesity; Rebaudioside A
- Publisher
- The Korean Society of Food Science and Technology
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Rebaudioside A (Reb A) and neohesperidin dihydrochalcone (NHDC) are known as intense sweeteners. This study aimed to examine the anti-obesity effects of Reb A and NHDC. C57BL/6 J-ob/ob mice were supplemented with Reb A (50 mg/kg body weight [b.w.]), NHDC (100 mg/kg b.w.), or their combination (COMB) for 4 weeks. COMB-supplemented mice showed significant reduction in b.w. gain, food efficiency ratio, and fat mass. Additionally, mice in the COMB group showed suppressed levels of genes related to adipogenesis, lipogenesis, and lipolysis in the perirenal fat and the levels of hepatic triglyceride, glutamic oxaloacetic transaminase, and glutamic pyruvic transaminase. The lipogenesis and pro-inflammatory gene expressions were also downregulated in the liver, whereas β-oxidation related genes were upregulated in the COMB group. In addition, mice that received COMB showed distinct gut microbiota structure, enriched in Blautia and Parabacteroides, and depleted in Faecalibaculum and Mucispirillum, in relation to the control group. These results suggest that supplementation with Reb A and NHDC may be an effective treatment for obesity-related metabolic disorders. © The Korean Society of Food Science and Technology 2023.
- DOI
- 10.1007/s10068-023-01391-1
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
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