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신산업융합대학
식품영양학과
Journal papers
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Magnetically assembled endothelial cell-coated spheroid for vascularization
Title
Magnetically assembled endothelial cell-coated spheroid for vascularization
Authors
Seok
;
Hodong
;
Roo
;
Dayeon
;
Cho
;
Sungwoo
;
Song
;
Wonmoon
;
Kim
;
Park
;
Tai Hyun
;
So
;
Kyoung-Ha
;
Hwang
;
Nathaniel S.
;
Jeong-Uk
Ewha Authors
박태현
SCOPUS Author ID
박태현
Issue Date
2024
Journal Title
Journal of Industrial and Engineering Chemistry
ISSN
1226-086X
Citation
Journal of Industrial and Engineering Chemistry vol. 134, pp. 484 - 494
Keywords
Cellular assembly
;
Engraftment
;
Magnetic nanoparticles
;
Spheroid
;
Transplantation
;
Vascularization
Publisher
Korean Society of Industrial Engineering Chemistry
Indexed
SCOPUS; KCI; SCIE
Document Type
Article
Abstract
3D spheroids are used as a therapeutic strategy and transplanted in vivo owing to their ability to better mimic the microphysiological environment that is crucial for the transplants to be able to engraft and vascularize for their long-term survival and functionalization in the host tissue. Among various methods of fabricating spheroids, the utilization of magnetic force enables rapid cell aggregation and spatial regulation. Encapsulating a magnetic spheroid with endothelial cells paves the way toward vascularization. Here, we magnetically bioprinted vascular assembly by coating magnetic spheroids with the magnetic nanoparticles (MNPs)-internalized vascular endothelial cells. MNPs-internalized mouse myoblasts cells (C2C12) were magnetically aggregated by placing a neodymium magnet under a well plate and then encapsulated by MNPs-internalized human umbilical vein endothelial cells (HUVECs). Internalization of MNPs did not hinder cell viability and vascularization-related gene expression, and the transplant of the vascular assemblies could sprout and be engrafted into the host tissue within three days. As these vascular assemblies are easily fabricated by coating spheroids with MNPs-internalized endothelial cells and controlled by a magnetic force, they may be used for engraftment and vascularization in various applications with spheroids with different functions. © 2024 The Korean Society of Industrial and Engineering Chemistry
DOI
10.1016/j.jiec.2024.01.011
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