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Gold Nanostructure-Based Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for Analysis of Small Biomolecules
- Title
- Gold Nanostructure-Based Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for Analysis of Small Biomolecules
- Authors
- Ji Hun; Kim; Young-Kwan; Cho; Hye-Sun; Seo; Tae Hoon; Park
- Ewha Authors
- 박지훈
- SCOPUS Author ID
- 박지훈
- Issue Date
- 2024
- Journal Title
- Mass Spectrometry Letters
- ISSN
- 2233-4203
- Citation
- Mass Spectrometry Letters vol. 15, no. 1, pp. 26 - 39
- Keywords
- gold nanostructure; laser; mass spectrometry; nanohybrid; small molecules
- Publisher
- Korean Society for Mass Spectrometry
- Indexed
- SCOPUS; KCI
- Document Type
- Review
- Abstract
- Gold nanostructures (Au NSs) are useful and interesting matrices for mass spectrometric analysis of various biomolecules based on organic matrix-free laser desorption/ionization time-of-flight mass spectrometry (LDI-TOF-MS). Au NSs provide high efficiency and versatility in LDI-TOF-MS analysis based on their well-established synthesis and surface functionalization, large surface area, high laser absorption capacity, and photothermal conversion efficiency. Therefore, Au NSs based LDI-TOF-MS can be a facile, functional, and efficient analytical method for important small biomolecules owing to its simple preparation, rapid analysis, salt-tolerance, signal reproducibility, and quantitative analysis. This review chronologically summarizes the important advance of Au NSs-based LDI-TOF-MS platforms in terms of in-depth mechanism, signal enhancement, quantitative analysis, and disease diagnosis. © Korean Society for Mass Spectrometry.
- DOI
- 10.5478/MSL.2024.15.1.26
- Appears in Collections:
- 사범대학 > 과학교육과 > Journal papers
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