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Construction of a bioactive copper-based metal organic framework-embedded dual-crosslinked alginate hydrogel for antimicrobial applications
- Title
- Construction of a bioactive copper-based metal organic framework-embedded dual-crosslinked alginate hydrogel for antimicrobial applications
- Authors
- Gwon K.; Lee S.; Kim Y.; Choi J.; Kim S.; Kim S.-J.; Hong H.J.; Hwang Y.; Mori M.; Lee D.N.
- Ewha Authors
- 김성진
- SCOPUS Author ID
- 김성진
- Issue Date
- 2023
- Journal Title
- International Journal of Biological Macromolecules
- ISSN
- 1418-8130
- Citation
- International Journal of Biological Macromolecules vol. 242
- Keywords
- Antimicrobial agent; Dual-crosslinking hydrogel; Metal organic framework
- Publisher
- Elsevier B.V.
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Metal-organic frameworks (MOFs) containing bioactive metals have the potential to exhibit antimicrobial activity by releasing metal ions or ligands through the cleavage of metal-ligand bonds. Recently, copper-based MOFs (Cu-MOFs) with sustained release capability, porosity, and structural flexibility have shown promising antimicrobial properties. However, for clinical use, the controlled release of Cu2+ over an extended time period is crucial to prevent toxicity. In this study, we developed an alginate-based antimicrobial scaffold and encapsulated MOFs within a dual-crosslinked alginate polymer network. We synthesized Cu-MOFs containing glutarate (Glu) and 4,4′-azopyridine (AZPY) (Cu(AZPY)-MOF) and encapsulated them in an alginate-based hydrogel through a combination of visible light-induced photo and calcium ion-induced chemical crosslinking processes. We confirmed Cu(AZPY)-MOF synthesis using scanning electron microscopy, transmission electron microscopy, powder X-ray diffraction, and thermogravimetric analysis. This antimicrobial hydrogel demonstrated excellent antibacterial and antifungal properties against two bacterial strains (MRSA and S. mutans, with >99.9 % antibacterial rate) and one fungal strain (C. albicans, with >78.7 % antifungal rate) as well as negligible cytotoxicity towards mouse embryonic fibroblasts, making it a promising candidate for various tissue engineering applications in biomedical fields. © 2023
- DOI
- 10.1016/j.ijbiomac.2023.124840
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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