Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김성진 | * |
dc.date.accessioned | 2023-07-31T16:31:09Z | - |
dc.date.available | 2023-07-31T16:31:09Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1418-8130 | * |
dc.identifier.other | OAK-33576 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/265299 | - |
dc.description.abstract | Metal-organic frameworks (MOFs) containing bioactive metals have the potential to exhibit antimicrobial activity by releasing metal ions or ligands through the cleavage of metal-ligand bonds. Recently, copper-based MOFs (Cu-MOFs) with sustained release capability, porosity, and structural flexibility have shown promising antimicrobial properties. However, for clinical use, the controlled release of Cu2+ over an extended time period is crucial to prevent toxicity. In this study, we developed an alginate-based antimicrobial scaffold and encapsulated MOFs within a dual-crosslinked alginate polymer network. We synthesized Cu-MOFs containing glutarate (Glu) and 4,4′-azopyridine (AZPY) (Cu(AZPY)-MOF) and encapsulated them in an alginate-based hydrogel through a combination of visible light-induced photo and calcium ion-induced chemical crosslinking processes. We confirmed Cu(AZPY)-MOF synthesis using scanning electron microscopy, transmission electron microscopy, powder X-ray diffraction, and thermogravimetric analysis. This antimicrobial hydrogel demonstrated excellent antibacterial and antifungal properties against two bacterial strains (MRSA and S. mutans, with >99.9 % antibacterial rate) and one fungal strain (C. albicans, with >78.7 % antifungal rate) as well as negligible cytotoxicity towards mouse embryonic fibroblasts, making it a promising candidate for various tissue engineering applications in biomedical fields. © 2023 | * |
dc.language | English | * |
dc.publisher | Elsevier B.V. | * |
dc.subject | Antimicrobial agent | * |
dc.subject | Dual-crosslinking hydrogel | * |
dc.subject | Metal organic framework | * |
dc.title | Construction of a bioactive copper-based metal organic framework-embedded dual-crosslinked alginate hydrogel for antimicrobial applications | * |
dc.type | Article | * |
dc.relation.volume | 242 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | International Journal of Biological Macromolecules | * |
dc.identifier.doi | 10.1016/j.ijbiomac.2023.124840 | * |
dc.identifier.wosid | WOS:001001460100001 | * |
dc.identifier.scopusid | 2-s2.0-85158870218 | * |
dc.author.google | Gwon K. | * |
dc.author.google | Lee S. | * |
dc.author.google | Kim Y. | * |
dc.author.google | Choi J. | * |
dc.author.google | Kim S. | * |
dc.author.google | Kim S.-J. | * |
dc.author.google | Hong H.J. | * |
dc.author.google | Hwang Y. | * |
dc.author.google | Mori M. | * |
dc.author.google | Lee D.N. | * |
dc.contributor.scopusid | 김성진(56812714700) | * |
dc.date.modifydate | 20240301081003 | * |