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Glycosylated and Succinylated Macrocyclic Lactones with Amyloid-beta-Aggregation-Regulating Activity from a Marine Bacillus sp.
- Title
- Glycosylated and Succinylated Macrocyclic Lactones with Amyloid-beta-Aggregation-Regulating Activity from a Marine Bacillus sp.
- Authors
- Cui, Jinsheng; Ye, Suhyun; Shin, Daniel; Cho, Illhwan; Kim, Hye Yun; Kwon, Yun; Park, Keunwan; Nam, Sang-Jip; Kim, YoungSoo; Oh, Dong-Chan
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2023
- Journal Title
- MARINE DRUGS
- ISSN
- 1660-3397
- Citation
- MARINE DRUGS vol. 21, no. 2
- Keywords
- glycosylation; succinylation; macrocyclic lactone; absolute configuration; Bacillus sp; amyloid-beta
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Two new glycosylated and succinylated macrocyclic lactones, succinyl glyco-oxydifficidin (1) and succinyl macrolactin O (2), were isolated from a Bacillus strain collected from an intertidal mudflat on Anmyeon Island in Korea. The planar structures of 1 and 2 were proposed using mass spectrometric analysis and NMR spectroscopic data. The absolute configurations of 1 and 2 were determined by optical rotation, J-based configuration analysis, chemical derivatizations, including the modified Mosher's method, and quantum-mechanics-based calculation. Biological evaluation of 1 and 2 revealed that succinyl glyco-oxydifficidin (1) inhibited/dissociated amyloid beta (A beta) aggregation, whereas succinyl macrolactin O (2) inhibited A beta aggregation, indicating their therapeutic potential for disassembling and removing A beta aggregation.
- DOI
- 10.3390/md21020067
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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