Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2023-04-14T16:31:10Z | - |
dc.date.available | 2023-04-14T16:31:10Z | - |
dc.date.issued | 2023 | * |
dc.identifier.issn | 1660-3397 | * |
dc.identifier.other | OAK-33144 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/264865 | - |
dc.description.abstract | Two new glycosylated and succinylated macrocyclic lactones, succinyl glyco-oxydifficidin (1) and succinyl macrolactin O (2), were isolated from a Bacillus strain collected from an intertidal mudflat on Anmyeon Island in Korea. The planar structures of 1 and 2 were proposed using mass spectrometric analysis and NMR spectroscopic data. The absolute configurations of 1 and 2 were determined by optical rotation, J-based configuration analysis, chemical derivatizations, including the modified Mosher's method, and quantum-mechanics-based calculation. Biological evaluation of 1 and 2 revealed that succinyl glyco-oxydifficidin (1) inhibited/dissociated amyloid beta (A beta) aggregation, whereas succinyl macrolactin O (2) inhibited A beta aggregation, indicating their therapeutic potential for disassembling and removing A beta aggregation. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | glycosylation | * |
dc.subject | succinylation | * |
dc.subject | macrocyclic lactone | * |
dc.subject | absolute configuration | * |
dc.subject | Bacillus sp | * |
dc.subject | amyloid-beta | * |
dc.title | Glycosylated and Succinylated Macrocyclic Lactones with Amyloid-beta-Aggregation-Regulating Activity from a Marine Bacillus sp. | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 21 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | MARINE DRUGS | * |
dc.identifier.doi | 10.3390/md21020067 | * |
dc.identifier.wosid | WOS:000941637300001 | * |
dc.identifier.scopusid | 2-s2.0-85148884854 | * |
dc.author.google | Cui, Jinsheng | * |
dc.author.google | Ye, Suhyun | * |
dc.author.google | Shin, Daniel | * |
dc.author.google | Cho, Illhwan | * |
dc.author.google | Kim, Hye Yun | * |
dc.author.google | Kwon, Yun | * |
dc.author.google | Park, Keunwan | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Kim, YoungSoo | * |
dc.author.google | Oh, Dong-Chan | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |