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Effect of Ecklonia cava polyphenol on adiposity reduction is associated with gut microbiota composition in subjects with abdominal obesity: A secondary analysis
- Title
- Effect of Ecklonia cava polyphenol on adiposity reduction is associated with gut microbiota composition in subjects with abdominal obesity: A secondary analysis
- Authors
- Lee, Yu Sim; Kang, Seunghee; Kang, Nayeon; Yu, Jaehong; Park, Taesung; Lee, Sunjae; Kwon, Oran
- Ewha Authors
- 권오란
- SCOPUS Author ID
- 권오란
- Issue Date
- 2022
- Journal Title
- JOURNAL OF FUNCTIONAL FOODS
- ISSN
- 1756-4646
2214-9414
- Citation
- JOURNAL OF FUNCTIONAL FOODS vol. 99
- Keywords
- Association; Human clinical trial; Gut microbiota; Obesity; Phlorotannin; Functional profile prediction
- Publisher
- ELSEVIER
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- A previous randomized controlled trial showed that Ecklonia cava polyphenol (EP) has the potential to reduce fat accumulation based on clinical outcomes and target gene expression analysis. Here, we investigated whether EP affects gut microbiota composition and impacts clinical outcomes. To this end, we analyzed 16S rRNA sequencing on fecal samples from subgroup subjects with abdominal obesity (n = 20/group). Compared with the placebo treatment, EP supplementation attenuated the increase of the Firmicutes-to-Bacteroidetes ratio and changed 18 genera composition, including genera related to obesity and fermentation of unabsorbed compounds. Furthermore, Spearman's correlation and Tax4Fun analysis demonstrated that alterations in genera are tightly associated with reducing adiposity via regulating oxidative stress. Together, these findings suggest that the gut microbiota-regulating effect might be a possible mechanism of EP-induced adiposity reduction in subjects with abdominal obesity.
- DOI
- 10.1016/j.jff.2022.105333
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
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