View : 380 Download: 0
Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy
- Title
- Hexa-BODIPY-cyclotriphosphazene based nanoparticle for NIR fluorescence/photoacoustic dual-modal imaging and photothermal cancer therapy
- Authors
- Kwon, Nahyun; Kim, Kwang H.; Park, Sinyoung; Cho, Yejin; Park, Eun-Yeong; Lim, Junha; Cetindere, Seda; Tumay, Sureyya Oguz; Kim, Won Jong; Li, Xingshu; Nam, Ki Taek; Kim, Chulhong; Yesilot, Serkan; Yoon, Juyoung
- Ewha Authors
- 윤주영
- SCOPUS Author ID
- 윤주영
- Issue Date
- 2022
- Journal Title
- BIOSENSORS & BIOELECTRONICS
- ISSN
- 0956-5663
1873-4235
- Citation
- BIOSENSORS & BIOELECTRONICS vol. 216
- Keywords
- NIR fluorescence Imaging; Photoacoustic imaging; Dual-modal imaging; Photothermal cancer therapy; Theragnostic nanoparticle
- Publisher
- ELSEVIER ADVANCED TECHNOLOGY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Theranostic, which integrates the diagnosis and tumor treatment in tandem, is an emerging strategy in cancer treatment. Here, we report a novel and unique theranostic nanoparticle, HBCP NP, based on hexa-BODIPY cyclophosphazene (HBCP). Due to the unique bulky molecular structure of HBCP, this nanoparticle can simultaneously perform near-infrared (NIR) fluorescence imaging and photoacoustic imaging (PAI). Interestingly, since reactive oxygen species (ROS) generation of HBCP NPs is completely inhibited, `safe' fluorescence imaging is possible without the risk of cell damage even under laser irradiation. Finally, NIR fluorescence imaging and PAI in 4T1 tumor-bearing mice demonstrated selective accumulation of HBCP NPs at tumor sites. In addition, HBCP NPs exhibited excellent photothermal effects under high-power laser irradiation, achieving effective tumor growth inhibition.
- DOI
- 10.1016/j.bios.2022.114612
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML