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Adenosine derivatives from Cordyceps exert antitumor effects against ovarian cancer cells through ENT1-mediated transport, induction of AMPK signaling, and consequent autophagic cell death
- Title
- Adenosine derivatives from Cordyceps exert antitumor effects against ovarian cancer cells through ENT1-mediated transport, induction of AMPK signaling, and consequent autophagic cell death
- Authors
- Yoon, So Young; Lindroth, Anders M.; Kwon, Soyoung; Park, Soo Jung; Park, Yoon Jung
- Ewha Authors
- 박윤정
- SCOPUS Author ID
- 박윤정
- Issue Date
- 2022
- Journal Title
- BIOMEDICINE & PHARMACOTHERAPY
- ISSN
- 0753-3322
1950-6007
- Citation
- BIOMEDICINE & PHARMACOTHERAPY vol. 153
- Keywords
- Cordyceps militaris; Adenosine derivatives; Ovarian cancer; Autophagy; ENT1; AMPK
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Cordyceps militaris is rich in adenosine derivatives, including 3 '-deoxyadenosine, also known as cordycepin. It has been reported for antitumor effects, but its underlying molecular mechanism has yet to be elucidated. We investigated how adenosine derivatives exerted antitumor effects against ovarian cancer using human ovarian cancer cells and a xenograft mouse model. Treatment with adenosine derivatives effectively resulted in cell death of ovarian cancer cells through AMPK activation and subsequently mTOR-mediated autophagic induction. Intriguingly, the effect required membrane transport of adenosine derivatives via ENT1, rather than ADORAmediated cellular signaling. Our data suggest that adenosine derivatives may be an effective therapeutic intervention in ovarian cancer through induction of ENT1-AMPK-mTOR-mediated autophagic cell death.
- DOI
- 10.1016/j.biopha.2022.113491
- Appears in Collections:
- 신산업융합대학 > 식품영양학과 > Journal papers
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