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Antibacterial Meroterpenoids, Merochlorins G-J from the Marine Bacterium Streptomyces sp.
- Title
- Antibacterial Meroterpenoids, Merochlorins G-J from the Marine Bacterium Streptomyces sp.
- Authors
- Ryu, Min-Ji; Hillman, Prima F.; Lee, Jihye; Hwang, Sunghoon; Lee, Eun-Young; Cha, Sun-Shin; Yang, Inho; Oh, Dong-Chan; Nam, Sang-Jip; Fenical, William
- Ewha Authors
- 남상집; 차선신
- SCOPUS Author ID
- 남상집; 차선신
- Issue Date
- 2021
- Journal Title
- MARINE DRUGS
- ISSN
- 1660-3397
- Citation
- MARINE DRUGS vol. 19, no. 11
- Keywords
- chlorinated meroterpenoid; merochlorins G J; dihydronaphthalenedione precursor; ECD; DP4; antibacterial
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Four new chlorinated meroterpenoids, merochlorins G-J (1-4), and 10, a dihydronaphthalenedione precursor, along with known merochlorins A (5) and C-F (6 9), were obtained from cultivation of the bacterium strain Streptomyces sp. CNH-189, which was isolated from marine sediment. The planar structures of compounds 1-4 and 10 were elucidated by interpretation of MS, UV, and NMR spectroscopic data. The relative configurations of compounds 1-4 were determined via analysis of nuclear Overhauser effect (NOE) spectroscopic data, after which their absolute configurations were established by comparing the experimental electronic circular dichroism (ECD) spectra of compounds 1-4 to those of previously reported possible enantiomer models and DP4 calculations. Compound 3 displayed strong antibacterial activities against Bacillus subtilis, Kocuria rhizophila, and Staphylococcus aureus, with MIC values of 1, 2, and 2 mu g/mL, respectively, whereas compound 1 exhibited weak antibacterial effects on these three strains, with a 16-32 mu g/mL MIC value range.
- DOI
- 10.3390/md19110618
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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