Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.contributor.author | 차선신 | * |
dc.date.accessioned | 2022-06-02T16:31:22Z | - |
dc.date.available | 2022-06-02T16:31:22Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1660-3397 | * |
dc.identifier.other | OAK-31351 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261301 | - |
dc.description.abstract | Four new chlorinated meroterpenoids, merochlorins G-J (1-4), and 10, a dihydronaphthalenedione precursor, along with known merochlorins A (5) and C-F (6 9), were obtained from cultivation of the bacterium strain Streptomyces sp. CNH-189, which was isolated from marine sediment. The planar structures of compounds 1-4 and 10 were elucidated by interpretation of MS, UV, and NMR spectroscopic data. The relative configurations of compounds 1-4 were determined via analysis of nuclear Overhauser effect (NOE) spectroscopic data, after which their absolute configurations were established by comparing the experimental electronic circular dichroism (ECD) spectra of compounds 1-4 to those of previously reported possible enantiomer models and DP4 calculations. Compound 3 displayed strong antibacterial activities against Bacillus subtilis, Kocuria rhizophila, and Staphylococcus aureus, with MIC values of 1, 2, and 2 mu g/mL, respectively, whereas compound 1 exhibited weak antibacterial effects on these three strains, with a 16-32 mu g/mL MIC value range. | * |
dc.language | English | * |
dc.publisher | MDPI | * |
dc.subject | chlorinated meroterpenoid | * |
dc.subject | merochlorins G J | * |
dc.subject | dihydronaphthalenedione precursor | * |
dc.subject | ECD | * |
dc.subject | DP4 | * |
dc.subject | antibacterial | * |
dc.title | Antibacterial Meroterpenoids, Merochlorins G-J from the Marine Bacterium Streptomyces sp. | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 19 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | MARINE DRUGS | * |
dc.identifier.doi | 10.3390/md19110618 | * |
dc.identifier.wosid | WOS:000773908500001 | * |
dc.author.google | Ryu, Min-Ji | * |
dc.author.google | Hillman, Prima F. | * |
dc.author.google | Lee, Jihye | * |
dc.author.google | Hwang, Sunghoon | * |
dc.author.google | Lee, Eun-Young | * |
dc.author.google | Cha, Sun-Shin | * |
dc.author.google | Yang, Inho | * |
dc.author.google | Oh, Dong-Chan | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Fenical, William | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.contributor.scopusid | 차선신(7201864593) | * |
dc.date.modifydate | 20240429134916 | * |