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Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine Streptomyces sp.
- Title
- Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine Streptomyces sp.
- Authors
- An J.S.; Kim M.-S.; Han J.; Jang S.C.; Im J.H.; Cui J.; Lee Y.; Nam S.-J.; Shin J.; Lee S.K.; Yoon Y.J.; Oh D.-C.
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2022
- Journal Title
- Journal of Natural Products
- ISSN
- 0163-3864
- Citation
- Journal of Natural Products vol. 85, no. 4, pp. 804 - 814
- Publisher
- American Chemical Society
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- A new nonribosomal peptide, nyuzenamide C (1), was discovered from riverine sediment-derived Streptomyces sp. DM14. Comprehensive analysis of the spectroscopic data of nyuzenamide C (1) revealed that 1 has a bicyclic backbone composed of six common amino acid residues (Asn, Leu, Pro, Gly, Val, and Thr) and four nonproteinogenic amino acid units, including hydroxyglycine, β-hydroxyphenylalanine, p-hydroxyphenylglycine, and 3,β-dihydroxytyrosine, along with 1,2-epoxypropyl cinnamic acid. The absolute configuration of 1 was proposed by J-based configuration analysis, the advanced Marfey's method, quantum mechanics-based DP4 calculations, and bioinformatic analysis of its nonribosomal peptide synthetase biosynthetic gene cluster. Nyuzenamide C (1) displayed antiangiogenic activity in human umbilical vein endothelial cells and induced quinone reductase in murine Hepa-1c1c7 cells. © 2022 American Chemical Society. All rights reserved.
- DOI
- 10.1021/acs.jnatprod.1c00837
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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