Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2022-06-02T16:31:05Z | - |
dc.date.available | 2022-06-02T16:31:05Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 0163-3864 | * |
dc.identifier.other | OAK-31458 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261205 | - |
dc.description.abstract | A new nonribosomal peptide, nyuzenamide C (1), was discovered from riverine sediment-derived Streptomyces sp. DM14. Comprehensive analysis of the spectroscopic data of nyuzenamide C (1) revealed that 1 has a bicyclic backbone composed of six common amino acid residues (Asn, Leu, Pro, Gly, Val, and Thr) and four nonproteinogenic amino acid units, including hydroxyglycine, β-hydroxyphenylalanine, p-hydroxyphenylglycine, and 3,β-dihydroxytyrosine, along with 1,2-epoxypropyl cinnamic acid. The absolute configuration of 1 was proposed by J-based configuration analysis, the advanced Marfey's method, quantum mechanics-based DP4 calculations, and bioinformatic analysis of its nonribosomal peptide synthetase biosynthetic gene cluster. Nyuzenamide C (1) displayed antiangiogenic activity in human umbilical vein endothelial cells and induced quinone reductase in murine Hepa-1c1c7 cells. © 2022 American Chemical Society. All rights reserved. | * |
dc.language | English | * |
dc.publisher | American Chemical Society | * |
dc.title | Nyuzenamide C, an Antiangiogenic Epoxy Cinnamic Acid-Containing Bicyclic Peptide from a Riverine Streptomyces sp. | * |
dc.type | Review | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 85 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 804 | * |
dc.relation.lastpage | 814 | * |
dc.relation.journaltitle | Journal of Natural Products | * |
dc.identifier.doi | 10.1021/acs.jnatprod.1c00837 | * |
dc.identifier.wosid | WOS:000791431400005 | * |
dc.identifier.scopusid | 2-s2.0-85127267245 | * |
dc.author.google | An J.S. | * |
dc.author.google | Kim M.-S. | * |
dc.author.google | Han J. | * |
dc.author.google | Jang S.C. | * |
dc.author.google | Im J.H. | * |
dc.author.google | Cui J. | * |
dc.author.google | Lee Y. | * |
dc.author.google | Nam S.-J. | * |
dc.author.google | Shin J. | * |
dc.author.google | Lee S.K. | * |
dc.author.google | Yoon Y.J. | * |
dc.author.google | Oh D.-C. | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |