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Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics
- Title
- Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics
- Authors
- Jeong, Keunsoo; Kim, Dojin; Kim, Hyun Jun; Lee, Yong-Deok; Yoo, Jounghyun; Jang, Dohyub; Lee, Seokyung; Park, Hyeonjong; Kim, Youngsun; Singh, Ajay; Ahn, Dong June; Kim, Dong Ha; Bang, Joona; Kim, Jungahn; Prasad, Paras N.; Kim, Sehoon
- Ewha Authors
- 김동하
- SCOPUS Author ID
- 김동하
- Issue Date
- 2021
- Journal Title
- ACS NANO
- ISSN
- 1936-0851
1936-086X
- Citation
- ACS NANO vol. 15, no. 11, pp. 18394 - 18402
- Keywords
- ultrasound; upconversion; near-infrared; microbubble; nanohybrid
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Hybrid nanostructures are promising for ultrasound-triggered drug delivery and treatment, called sonotheranostics. Structures based on plasmonic nanoparticles for photothermal-induced microbubble inflation for ultrasound imaging exist. However, they have limited therapeutic applications because of short microbubble lifetimes and limited contrast. Photochemistry-based sonotheranostics is an attractive alternative, but building near-infrared (NIR)-responsive echogenic nanostructures for deep tissue applications is challenging because photolysis requires high-energy (UV-visible) photons. Here, we report a photochemistry-based echogenic nanoparticle for in situ NIR-controlled ultrasound imaging and ultrasound-mediated drug delivery. Our nanoparticle has an upconversion nanoparticle core and an organic shell carrying gas generator molecules and drugs. The core converts low-energy NIR photons into ultraviolet emission for photolysis of the gas generator. Carbon dioxide gases generated in the tumor-penetrated nanoparticle inflate into microbubbles for sonotheranostics. Using different NIR laser power allows dual-modal upconversion luminescence planar imaging and cross-sectional ultrasonography. Low-frequency (10 MHz) ultrasound stimulated microbubble collapse, releasing drugs deep inside the tumor through cavitation-induced transport. We believe that the photoechogenic inflatable hierarchical nanostructure approach introduced here can have broad applications for image-guided multimodal theranostics.
- DOI
- 10.1021/acsnano.1c07898
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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